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• W79891073 endingPage "87" @default.
• W79891073 startingPage "71" @default.
• W79891073 abstract "Thrombosis underlies most acute manifestations of coronary atherosclerotic disease, including myocardial infarction (MI) [1]. In this setting, the rupture of an atherosclerotic plaque, endothelial cell damage, or both, are the key events that trigger the thrombotic process. Plaque disruption is followed by the exposure of blood flow to tissue factor (TF), a glycoprotein elaborated by several cells infiltrating the plaque, which is accumulated especially in the lipid-rich core [2]. TF forms a high-affinity complex with coagulation factor VII [3], which initiates a cascade of enzymatic reactions resulting in the local generation of thrombin and deposition of fibrin. The evolution to occ1usive thrombus or resolving lesion is depending on a delicate equilibrium between thrombosis and endogenous thrombolysis. As part of the response to any type of endothelial wall disruption, platelet adhesion occurs through the binding of the glycoprotein (Gp) Ib/IX/V platelet receptor to von Willebrand Factor (vWF) and/or direct binding of platelets by means of their collagen receptor (Gp Ia/IIa complex). These reactions determine a conformational change in the platelet Gp IIb/IIIa integrin, from a ligand-unreceptive state to a ligand-receptive state. Ligand-receptive Gp IIb/IIIa receptors bind fibrinogen molecules, which form bridges between adjacent platelets, facilitating platelet aggregation and propagation of thrombus [4,5].KeywordsFactor VersusPlasminogen Activator InhibitorFactor Versus LeidenFactor VersusProthrombin GeneThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves." @default.
• W79891073 created "2016-06-24" @default.
• W79891073 creator A5023996952 @default.
• W79891073 creator A5041970756 @default.
• W79891073 creator A5065645344 @default.
• W79891073 date "2001-01-01" @default.
• W79891073 modified "2023-09-27" @default.
• W79891073 title "Genetic Markers of Hemostatic Factors" @default.
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