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- W799070785 abstract "In this study we investigate the subcellular localisation of flotillin under the influence of cholesterol. We demonstrate that the cellular localisation is dependent on the level of cellular cholesterol. Depletion of cholesterol recruits flotillin to the plasma membrane, whereas cholesterol overload drives flotillin to endosomal structures. These movements are dependent on the integrity of the cytoskeleton. Additionally, this work shows that these movements are dependent on two putative cholesterol-binding/-interaction-domains. Our data gives hints for a transport of cholesterol connected to flotillin into the late endosome. In further investigations our group could demonstrate that the exosomal release of cholesterol increases with increasing intracellular cholesterol and that this choleterol release is dependent on flotillin. Our data points towards a potential role of flotillin and exosomes for the homeostasis of cellular cholesterol." @default.
- W799070785 created "2016-06-24" @default.
- W799070785 creator A5017425064 @default.
- W799070785 date "2022-02-20" @default.
- W799070785 modified "2023-10-03" @default.
- W799070785 title "Cholesterinabhängige subzelluläre Lokalisation von Flotillin" @default.
- W799070785 doi "https://doi.org/10.53846/goediss-3820" @default.
- W799070785 hasPublicationYear "2022" @default.
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