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• W80004693 startingPage "569" @default.
• W80004693 abstract "Animal cells internalize many different macromolecules from their environment. A large percentage of these materials, including many polypeptide hormones, are selected from the surrounding medium by binding to specific receptors on the cell surface. The internalization of these receptor-bound molecules is rapid and highly specific. The general pathway of entry involves assembly of clusters of ligand-receptor complexes in clathrin-coated pits of the plasma membrane, formation of intracellular endocytic vesicles called receptosomes (or endosomes) from these coated pits, saltatory movement of these vesicles to the Golgi system, selective fusion of these receptosomes with the trans-reticular elements of the Golgi, and routing by as yet unknown mechanisms either to lysosomes, or back out of the cell by constitutive exocytosis. Some receptors accompany the ligand into lysosomes where they are degraded, whereas others appear to separate from the ligand and are recycled back to the cell surface; ligands such as transferrin are not delivered to lysosomes, but appear to accompany the receptor back to the cell exterior. Similar processes may be involved in the intracellular routing of materials synthesized in the endoplasmic reticulum. Intracellular traffic control may be in some ways analogous to traffic control at the cell surface in the requirement for specific receptors, and the use of clathrin-coated regions of membrane. Certain disease-causing substances, such as bacterial toxins and viruses, have taken advantage of this pathway to gain entrance to the cell. The endocytic pathway probably has a significant role in hormone action either directly or indirectly by the regulation of surface receptor numbers, or the transport of carrier molecules or other molecules involved in the mechanisms of action of hormones." @default.
• W80004693 created "2016-06-24" @default.
• W80004693 creator A5056573254 @default.
• W80004693 creator A5085840629 @default.
• W80004693 date "1984-01-01" @default.
• W80004693 modified "2023-10-16" @default.
• W80004693 title "Endocytosis and Membrane Traffic in Cultured Cells" @default.
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• W80004693 doi "https://doi.org/10.1016/b978-0-12-571140-1.50018-9" @default.
• W80004693 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6207568" @default.
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