Matches in SemOpenAlex for { <https://semopenalex.org/work/W800314662> ?p ?o ?g. }
- W800314662 endingPage "369" @default.
- W800314662 startingPage "361" @default.
- W800314662 abstract "Flavour ingredients are an essential part of e-liquids. Their responsible selection and inclusion levels in e-liquids must be guided by toxicological principles. We propose an approach to the screening and toxicological risk assessment of flavour ingredients for e-liquids. The screening involves purity requirements and avoiding ingredients that are carcinogenic, mutagenic or toxic to reproduction. Additionally, owing to the uncertainties involved in potency determination and the derivation of a tolerable level for respiratory sensitisation, we propose excluding respiratory sensitisers. After screening, toxicological data on the ingredients should be reviewed. Inhalation-specific toxicological issues, for which no reliable safe levels can currently be derived, can lead to further ingredient exclusions. We discuss the use of toxicological thresholds of concern for flavours that lack inhalation data suitable for quantitative risk assessment. Higher toxicological thresholds of concern are suggested for flavour ingredients (170 or 980μg/day) than for contaminant assessment (1.5μg/day). Analytical detection limits for measurements of potential reaction and thermal breakdown products in vaping aerosol, should be informed by the contaminant threshold. This principle leads us to recommend 5ng/puff as an appropriate limit of detection for untargeted aerosol measurements." @default.
- W800314662 created "2016-06-24" @default.
- W800314662 creator A5020052455 @default.
- W800314662 creator A5066284428 @default.
- W800314662 date "2015-07-01" @default.
- W800314662 modified "2023-09-26" @default.
- W800314662 title "An approach to ingredient screening and toxicological risk assessment of flavours in e-liquids" @default.
- W800314662 cites W1968942490 @default.
- W800314662 cites W1969956529 @default.
- W800314662 cites W1984369865 @default.
- W800314662 cites W1993670625 @default.
- W800314662 cites W1999183008 @default.
- W800314662 cites W2011371303 @default.
- W800314662 cites W2013895319 @default.
- W800314662 cites W2018984280 @default.
- W800314662 cites W2019206282 @default.
- W800314662 cites W2028343202 @default.
- W800314662 cites W2032092418 @default.
- W800314662 cites W2042627917 @default.
- W800314662 cites W2052070977 @default.
- W800314662 cites W2061052534 @default.
- W800314662 cites W2065889499 @default.
- W800314662 cites W2078372881 @default.
- W800314662 cites W2085482546 @default.
- W800314662 cites W2086693751 @default.
- W800314662 cites W2087322923 @default.
- W800314662 cites W2088436316 @default.
- W800314662 cites W2089816226 @default.
- W800314662 cites W2092444528 @default.
- W800314662 cites W2116623625 @default.
- W800314662 cites W2130270812 @default.
- W800314662 cites W2135288761 @default.
- W800314662 cites W2138386700 @default.
- W800314662 cites W2146784275 @default.
- W800314662 cites W2149060543 @default.
- W800314662 cites W2150540243 @default.
- W800314662 cites W2152768965 @default.
- W800314662 cites W2156992505 @default.
- W800314662 cites W2164919479 @default.
- W800314662 cites W2168183334 @default.
- W800314662 cites W2461429104 @default.
- W800314662 cites W4211005442 @default.
- W800314662 cites W4251980620 @default.
- W800314662 doi "https://doi.org/10.1016/j.yrtph.2015.05.018" @default.
- W800314662 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26026505" @default.
- W800314662 hasPublicationYear "2015" @default.
- W800314662 type Work @default.
- W800314662 sameAs 800314662 @default.
- W800314662 citedByCount "51" @default.
- W800314662 countsByYear W8003146622016 @default.
- W800314662 countsByYear W8003146622017 @default.
- W800314662 countsByYear W8003146622018 @default.
- W800314662 countsByYear W8003146622019 @default.
- W800314662 countsByYear W8003146622020 @default.
- W800314662 countsByYear W8003146622021 @default.
- W800314662 countsByYear W8003146622022 @default.
- W800314662 countsByYear W8003146622023 @default.
- W800314662 crossrefType "journal-article" @default.
- W800314662 hasAuthorship W800314662A5020052455 @default.
- W800314662 hasAuthorship W800314662A5066284428 @default.
- W800314662 hasBestOaLocation W8003146621 @default.
- W800314662 hasConcept C105702510 @default.
- W800314662 hasConcept C12174686 @default.
- W800314662 hasConcept C127413603 @default.
- W800314662 hasConcept C16281581 @default.
- W800314662 hasConcept C183696295 @default.
- W800314662 hasConcept C185592680 @default.
- W800314662 hasConcept C2776954882 @default.
- W800314662 hasConcept C2780589914 @default.
- W800314662 hasConcept C31903555 @default.
- W800314662 hasConcept C33070731 @default.
- W800314662 hasConcept C38652104 @default.
- W800314662 hasConcept C41008148 @default.
- W800314662 hasConcept C45904493 @default.
- W800314662 hasConcept C71924100 @default.
- W800314662 hasConcept C86803240 @default.
- W800314662 hasConcept C98274493 @default.
- W800314662 hasConceptScore W800314662C105702510 @default.
- W800314662 hasConceptScore W800314662C12174686 @default.
- W800314662 hasConceptScore W800314662C127413603 @default.
- W800314662 hasConceptScore W800314662C16281581 @default.
- W800314662 hasConceptScore W800314662C183696295 @default.
- W800314662 hasConceptScore W800314662C185592680 @default.
- W800314662 hasConceptScore W800314662C2776954882 @default.
- W800314662 hasConceptScore W800314662C2780589914 @default.
- W800314662 hasConceptScore W800314662C31903555 @default.
- W800314662 hasConceptScore W800314662C33070731 @default.
- W800314662 hasConceptScore W800314662C38652104 @default.
- W800314662 hasConceptScore W800314662C41008148 @default.
- W800314662 hasConceptScore W800314662C45904493 @default.
- W800314662 hasConceptScore W800314662C71924100 @default.
- W800314662 hasConceptScore W800314662C86803240 @default.
- W800314662 hasConceptScore W800314662C98274493 @default.
- W800314662 hasIssue "2" @default.
- W800314662 hasLocation W8003146621 @default.
- W800314662 hasLocation W8003146622 @default.
- W800314662 hasOpenAccess W800314662 @default.
- W800314662 hasPrimaryLocation W8003146621 @default.