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- W80041609 abstract "Cloning by somatic cell nuclear transfer (SCNT) is a reproductive technique that is expected to contribute to industrial, medical, and environmental fields of research and application. However, its extremely low efficiency has hampered practical applications. From our studies using mice, we found that there was a high correlation between development beyond the two-cell stage and birth rates of SCNT embryos, suggesting that their fate was predetermined in early stages of embryogenesis. Therefore, we analyzed the global gene expression profiles of mouse SCNT-derived blastocysts to assess any reprogramming aberrations in the somatic nuclear donor cell genome. We found clone-specific X-linked gene repression caused by ectopic X-inactive specific transcript (Xist) RNA expression. We also succeeded in dramatically improving the birth rate of clones by correcting ectopic Xist transcription. SCNT studies focusing on Xist regulation in early embryos should not only accelerate practical applications of cloning techniques but also enhance our understanding of the mechanisms underlying the establishment and erasure of imprinted X-chromosome inactivation." @default.
- W80041609 created "2016-06-24" @default.
- W80041609 creator A5022850583 @default.
- W80041609 creator A5031145281 @default.
- W80041609 date "2014-01-01" @default.
- W80041609 modified "2023-09-30" @default.
- W80041609 title "Clone-Specific X-Linked Gene Repression Caused by Ectopic Xist Transcripts from the Active X Chromosome" @default.
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