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- W80043557 abstract "Throughout their lifespan all free-living organisms encounter diverse chemical and physical environmental and endogenous factors leading to DNA damage. Since DNA is a highly reactive macromolecule, these damages may affect both bases and the sugar-phosphate backbone and may lead to a severe dysfunction or death of organism. Already, at the early stages of the evolution, the mechanisms dedicated for repairing various DNA damages were developed. Cellular responses to DNA damage may be classified into two major groups: (i) tolerance and (ii) repair mechanisms. Tolerance mechanism, represented for example by translesion DNA synthesis, gives the cell a possibility to function further as if no damage had occurred. For the damages that cannot be tolerated, the repair mechanisms developed restore the structure of DNA molecule as close to its natural state as prior to damage. To fulfil this task repair mechanisms demonstrate high level of “intelligence” composed of outstanding sensitivity and specificity. One of the most important repair mechanisms is nucleotide excision repair (NER) which is a complex system responsible for recognition and removal of a wide spectra of DNA lesions. In eukaryotes components of NER may also be involved in other repair pathways and in various aspects of DNA metabolism. The importance of NER is supported by the fact that defects in NER cause an extreme ultraviolet (UV) sensitivity and lead to inherited disease such as xeroderma pigmentosum in humans.," @default.
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- W80043557 date "2008-11-29" @default.
- W80043557 modified "2023-10-18" @default.
- W80043557 title "The Nucleotide Excision Repair of DNA in Human Cells and Its Association with Xeroderma Pigmentosum" @default.
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- W80043557 doi "https://doi.org/10.1007/978-0-387-09599-8_12" @default.
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