FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W800508541> ?p ?o ?g. }

• W800508541 endingPage "338" @default.
• W800508541 startingPage "328" @default.
• W800508541 abstract "The misfolding and aggregation of the Aβ peptide - a fundamental event in the pathogenesis of Alzheimer׳s disease - can be instigated in the brains of experimental animals by the intracranial infusion of brain extracts that are rich in aggregated Aβ. Recent experiments have found that the peripheral (intraperitoneal) injection of Aβ seeds induces Aβ deposition in the brains of APP-transgenic mice, largely in the form of cerebral amyloid angiopathy. Macrophage-type cells normally are involved in pathogen neutralization and antigen presentation, but under some circumstances, circulating monocytes have been found to act as vectors for the transport of pathogenic agents such as viruses and prions. The present study assessed the ability of peripheral monocytes to transport Aβ aggregates from the peritoneal cavity to the brain. Our initial experiments showed that intravenously delivered macrophages that had previously ingested fluorescent nanobeads as tracers migrate primarily to peripheral organs such as spleen and liver, but that a small number also reach the brain parenchyma. We next injected CD45.1-expressing monocytes from donor mice intravenously into CD45.2-expressing host mice; after 24h, analysis by fluorescence-activated cell sorting (FACS) and histology confirmed that some CD45.1 monocytes enter the brain, particularly in the superficial cortex and around blood vessels. When the donor monocytes are first exposed to Aβ-rich brain extracts from human AD cases, a subset of intravenously delivered Aβ-containing cells migrate to the brain. These experiments indicate that, in mouse models, circulating monocytes are potential vectors by which exogenously delivered, aggregated Aβ travels from periphery to brain, and more generally support the hypothesis that macrophage-type cells can participate in the dissemination of proteopathic seeds." @default.
• W800508541 created "2016-06-24" @default.
• W800508541 creator A5009229220 @default.
• W800508541 creator A5009238597 @default.
• W800508541 creator A5011122184 @default.
• W800508541 creator A5017808777 @default.
• W800508541 creator A5072687821 @default.
• W800508541 date "2015-10-01" @default.
• W800508541 modified "2023-09-25" @default.
• W800508541 title "Transport of cargo from periphery to brain by circulating monocytes" @default.
• W800508541 cites W1486297307 @default.
• W800508541 cites W1493986974 @default.
• W800508541 cites W1505737561 @default.
• W800508541 cites W1509766815 @default.
• W800508541 cites W1511575292 @default.
• W800508541 cites W1548436366 @default.
• W800508541 cites W1561070497 @default.
• W800508541 cites W1565265443 @default.
• W800508541 cites W1595078459 @default.
• W800508541 cites W1785054298 @default.
• W800508541 cites W1826726928 @default.
• W800508541 cites W1928837524 @default.
• W800508541 cites W1935439593 @default.
• W800508541 cites W1966312717 @default.
• W800508541 cites W1966763839 @default.
• W800508541 cites W1967187624 @default.
• W800508541 cites W1967266384 @default.
• W800508541 cites W1971487740 @default.
• W800508541 cites W1973113152 @default.
• W800508541 cites W1977267085 @default.
• W800508541 cites W1979415323 @default.
• W800508541 cites W1982797857 @default.
• W800508541 cites W1991462232 @default.
• W800508541 cites W1995281235 @default.
• W800508541 cites W1996320585 @default.
• W800508541 cites W1999886226 @default.
• W800508541 cites W2000917982 @default.
• W800508541 cites W2002047195 @default.
• W800508541 cites W2002432566 @default.
• W800508541 cites W2003870922 @default.
• W800508541 cites W2005483591 @default.
• W800508541 cites W2005755021 @default.
• W800508541 cites W2011476386 @default.
• W800508541 cites W2012930166 @default.
• W800508541 cites W2015141049 @default.
• W800508541 cites W2021267750 @default.
• W800508541 cites W2022047142 @default.
• W800508541 cites W2023175337 @default.
• W800508541 cites W2024262813 @default.
• W800508541 cites W2024965367 @default.
• W800508541 cites W2029906813 @default.
• W800508541 cites W2029978572 @default.
• W800508541 cites W2032559950 @default.
• W800508541 cites W2034147064 @default.
• W800508541 cites W2035339855 @default.
• W800508541 cites W2044224359 @default.
• W800508541 cites W2045262404 @default.
• W800508541 cites W2045720033 @default.
• W800508541 cites W2046096265 @default.
• W800508541 cites W2047555789 @default.
• W800508541 cites W2053082937 @default.
• W800508541 cites W2054540776 @default.
• W800508541 cites W2058092975 @default.
• W800508541 cites W2058690468 @default.
• W800508541 cites W2067147307 @default.
• W800508541 cites W2067412834 @default.
• W800508541 cites W2071753918 @default.
• W800508541 cites W2071967414 @default.
• W800508541 cites W2073957730 @default.
• W800508541 cites W2075133203 @default.
• W800508541 cites W2077917860 @default.
• W800508541 cites W2078004577 @default.
• W800508541 cites W2080006310 @default.
• W800508541 cites W2081374651 @default.
• W800508541 cites W2082429191 @default.
• W800508541 cites W2087886093 @default.
• W800508541 cites W2088079659 @default.
• W800508541 cites W2092131832 @default.
• W800508541 cites W2094930641 @default.
• W800508541 cites W2096410114 @default.
• W800508541 cites W2096876707 @default.
• W800508541 cites W2098022922 @default.
• W800508541 cites W2099340107 @default.
• W800508541 cites W2105385589 @default.
• W800508541 cites W2115236324 @default.
• W800508541 cites W2116784956 @default.
• W800508541 cites W2120130639 @default.
• W800508541 cites W2125660198 @default.
• W800508541 cites W2125841464 @default.
• W800508541 cites W2131222480 @default.
• W800508541 cites W2131261387 @default.
• W800508541 cites W2133007412 @default.
• W800508541 cites W2136188258 @default.
• W800508541 cites W2138327137 @default.
• W800508541 cites W2140139281 @default.
• W800508541 cites W2148034536 @default.
• W800508541 cites W2154910659 @default.
• W800508541 cites W2159560463 @default.

• next