Matches in SemOpenAlex for { <https://semopenalex.org/work/W80053785> ?p ?o ?g. }
- W80053785 endingPage "196" @default.
- W80053785 startingPage "171" @default.
- W80053785 abstract "Paneth cells are specialized intestinal epithelial cells found mainly in the crypts of the small intestine. Paneth cells should be viewed as provisional until they can be confirmed by more specific markers. The presence of antimicrobial proteins in Paneth cells, which are secreted in response to bacterial products, implicates these cells in host defense against infection as part of the innate immune system. Paneth cells are present in the fetal intestine, although numbers are low at birth and increase postnatally, independently of the presence of intestinal microorganisms. The functions of Paneth cells are largely surmised from their repertoire of expressed genes, while direct experimentation has also confirmed a definite role in protection against enteric bacterial infection. In zinc deficiency, Paneth cell morphology is altered, and although metallothionein declines to undetectable levels in most epithelial cells, it can still be detected in the cytoplasm of Paneth cells. The location of Paneth cells adjacent to the stem cell zone of the small intestinal crypts has led to speculation that they play some role in maintaining stem cell function. Necrotizing enterocolitis (NEC) is probably triggered by intestinal infection, and inflammation and ischemia localized to the terminal ileum are prominent pathological features. Expression of antimicrobial genes, and experimental studies showing that Paneth cells respond to bacterial products and are required for enteric host defense, establish them as a significant component of innate immunity in the intestine." @default.
- W80053785 created "2016-06-24" @default.
- W80053785 creator A5070486751 @default.
- W80053785 date "2014-04-09" @default.
- W80053785 modified "2023-09-23" @default.
- W80053785 title "Paneth Cells in Innate Immunity and Intestinal Inflammation" @default.
- W80053785 cites W126340564 @default.
- W80053785 cites W1489303781 @default.
- W80053785 cites W1553045378 @default.
- W80053785 cites W1557782384 @default.
- W80053785 cites W1565188629 @default.
- W80053785 cites W1632453688 @default.
- W80053785 cites W1632564255 @default.
- W80053785 cites W1670573097 @default.
- W80053785 cites W1847489898 @default.
- W80053785 cites W1897551156 @default.
- W80053785 cites W1944529636 @default.
- W80053785 cites W1967803785 @default.
- W80053785 cites W1969843034 @default.
- W80053785 cites W1970666565 @default.
- W80053785 cites W1974236378 @default.
- W80053785 cites W1974963144 @default.
- W80053785 cites W1976388047 @default.
- W80053785 cites W1976846347 @default.
- W80053785 cites W1979118603 @default.
- W80053785 cites W1979906012 @default.
- W80053785 cites W1981083234 @default.
- W80053785 cites W1982525385 @default.
- W80053785 cites W1986139763 @default.
- W80053785 cites W1987513354 @default.
- W80053785 cites W1987964722 @default.
- W80053785 cites W1991625690 @default.
- W80053785 cites W1991725063 @default.
- W80053785 cites W1991819438 @default.
- W80053785 cites W1992641427 @default.
- W80053785 cites W1993852539 @default.
- W80053785 cites W1996567795 @default.
- W80053785 cites W1996604552 @default.
- W80053785 cites W1997939575 @default.
- W80053785 cites W1998395322 @default.
- W80053785 cites W1999708798 @default.
- W80053785 cites W2001439699 @default.
- W80053785 cites W2003852197 @default.
- W80053785 cites W2004751481 @default.
- W80053785 cites W2005599373 @default.
- W80053785 cites W2008566847 @default.
- W80053785 cites W2009036660 @default.
- W80053785 cites W2013636295 @default.
- W80053785 cites W2014726627 @default.
- W80053785 cites W2014860961 @default.
- W80053785 cites W2014987173 @default.
- W80053785 cites W2016879562 @default.
- W80053785 cites W2017725062 @default.
- W80053785 cites W2019756308 @default.
- W80053785 cites W2024680306 @default.
- W80053785 cites W2026791548 @default.
- W80053785 cites W2034035840 @default.
- W80053785 cites W2034132167 @default.
- W80053785 cites W2034901235 @default.
- W80053785 cites W2035538797 @default.
- W80053785 cites W2035594567 @default.
- W80053785 cites W2035992593 @default.
- W80053785 cites W2046529045 @default.
- W80053785 cites W2051381725 @default.
- W80053785 cites W2052540984 @default.
- W80053785 cites W2054493318 @default.
- W80053785 cites W2055812124 @default.
- W80053785 cites W2056172754 @default.
- W80053785 cites W2058703787 @default.
- W80053785 cites W2059382129 @default.
- W80053785 cites W2059750002 @default.
- W80053785 cites W2060928105 @default.
- W80053785 cites W2061321571 @default.
- W80053785 cites W2061927074 @default.
- W80053785 cites W2062729850 @default.
- W80053785 cites W2064120562 @default.
- W80053785 cites W2067526109 @default.
- W80053785 cites W2068400261 @default.
- W80053785 cites W2070380466 @default.
- W80053785 cites W2073869570 @default.
- W80053785 cites W2074756239 @default.
- W80053785 cites W2078040205 @default.
- W80053785 cites W2080402588 @default.
- W80053785 cites W2080920508 @default.
- W80053785 cites W2081134892 @default.
- W80053785 cites W2082425861 @default.
- W80053785 cites W2083636455 @default.
- W80053785 cites W2083948098 @default.
- W80053785 cites W2085457180 @default.
- W80053785 cites W2086607027 @default.
- W80053785 cites W2087840051 @default.
- W80053785 cites W2090575145 @default.
- W80053785 cites W2091721221 @default.
- W80053785 cites W2091820797 @default.
- W80053785 cites W2093698498 @default.
- W80053785 cites W2094743639 @default.
- W80053785 cites W2101724872 @default.
- W80053785 cites W2102152294 @default.