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- W800710423 abstract "Objective To investigate the effects of folic acid on apoptosis of neural cells after focal cerebral ischemia injury in rats and the mechanisms.Method Thirty two adult male Sprague-Dawley(SD) rats were randomly divided into sham operation group(SO),middle cerebral artery occlusion group(MCAO),MCAO+ low dose folic acid group(MCAO+FA-L) and MCAO+ high dose folic acid group(MCAO+FA-H).The model of middle cerebral artery occlusion(MCAO) was set up by using intraluminal filament method.The rats were sacrificed at D7 day after cerebral ischemia.The apoptotic rate of neural cells was examined by TUNEL test,and the expression of pERK1/2 protein was detected by Western blotting method,The MDA content and serum SOD and GSH-Px activities in rats were measured before and 28d after folic acid treatment and 7th day after ischemia.Results Compared with ischemia group,the apoptotic rate of neural cells and MDA content in both folic acid supplemented groups were decreased significantly(P0.01),and the activities of SOD and GSH-Px in serum and pERK1/2 protein expression in both folic acid treated group were increased significantly(P0.01).Conclusion Folic acid can decrease apoptosis of neural cells of rats with cerebral ischemia,Through possible mechanisms of enhancing antioxidative enzymatic activities,inhibition of lipid hyperoxidation,and up-regulation of pERK1/2 protein expression,it has protective effect on the injury of ischemia." @default.
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- W800710423 date "2009-01-01" @default.
- W800710423 modified "2023-09-26" @default.
- W800710423 title "EFFECTS OF FOLIC ACID ON APOPTOSIS OF NEURAL CELLS IN RATS WITH FOCAL CEREBRAL ISCHEMIA INJURY" @default.
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