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- W80115170 abstract "Estrogen sulfotransferase (SULT1E1) is a cytosolic enzyme that catalyzes the sulfo-conjugation and inactivation of estrogens. It is expressed in the adult type of Leydig cells under the control of luteinizing hormone and androgen. Absence of Sultlel in the mouse leads to estrogen-induced Leydig cell hyperplasia and seminiferous tubule atrophy, abnormal accumulation of cholesterol ester and increased sensitivity to estrogen-induced steroidogenic lesion. The biochemical defects in Sultlel-deficient Leydig cells is associated with the induction of scavenger receptor class B type-I (SR-BI), which leads to increased high density lipid-cholesterol uptake, and suppression of CYP17 expression and activity. It is concluded that SULT1E1 plays a physiological role in protecting Leydig cells and seminiferous tubules from excessive stimulation by the testis-produced estrogens and its inhibition by environmental chemicals, as recently demonstrated for derivatives of polychlorinated biphenyl, might have repercussions for human reproductive health." @default.
- W80115170 created "2016-06-24" @default.
- W80115170 creator A5013389489 @default.
- W80115170 date "2007-10-27" @default.
- W80115170 modified "2023-09-26" @default.
- W80115170 title "The Role of Estrogen Sulfotransferase in Leydig Cells" @default.
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- W80115170 doi "https://doi.org/10.1007/978-1-59745-453-7_14" @default.
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