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- W801422441 abstract "Examinations involved 135 male Wistar rats weighing 200±11 g. After one-week acclimatization the animals were randomly assigned to three groups of 45 animals each. Rats in groups 1 (controls) fed a standard laboratory chow (Agros Poland, containing 4.9 mg Cu/kg) and tap water ad libitum. Rats in group 2 were fed the same diet as in group 1 and additionally treated with CdCl2 given orally by a stomach tube for 28 days (water solution) at a dose corresponding to 10 mg of cadmium per kg of diet. Rats in group 3 were treated with cadmium as in group 2 but fed the standard laboratory chow supplemented with copper as CuSO4 up to 49 mg/kg while manufacturing. The total dose of cadmium was about 7.8 mg. The consumption of feed and water, and body weight gains were evaluated weekly during the whole experimental period. Animals (5 rats at each time point) were killed at 7, 14, 21, and 28 days within the dosing period by immersion in gaseous carbon dioxide between 10:00 and 11:00 a.m. to minimize the durnal variation of the parameters examined. At necropsy the liver and kidneys were removed, weighed, homogenized and centrifuged at 4oC at 9000 g for 10 min. GSH levels were estimated by the method of Ellman modified by Griffin. The significance of the results was determined by Student’s test at P < 0.05. Results indicated that all the rats examined showed no alterations in feed and water intake, and organ to body ratios although a marked increase in body weight gain was found in rats from group 3 as compared with that in rats exposed to cadmium but not fed a copper enriched diet. Rats intoxicated with cadmium increased temporary hepatic and renal GSH levels as compared with those in group 1. On the other hand, hepatic GSH levels in rats fed a copper supplemented diet and treated with cadmium increased significantly in comparison to those in groups 1 and 2 whereas renal GSH levels increases were temporary." @default.
- W801422441 created "2016-06-24" @default.
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- W801422441 date "2008-01-01" @default.
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- W801422441 title "Influence of copper on renal and hepatic glutathione content in rats intoxicated with cadmium" @default.
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