Matches in SemOpenAlex for { <https://semopenalex.org/work/W801469215> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W801469215 endingPage "321" @default.
- W801469215 startingPage "316" @default.
- W801469215 abstract "All the pharmacological studies of LB17522 described here were carried out with high doses (fifteen to sixty times of the therapeutic dose) to determine an indication of potential side effects in clinical use in terms of the acute clinical signs, cardiovascular and central nervous system. LB10522 does not produce any observable clinical signs except for the symptoms such as moist eye, skin rash, slight salivation, vomitting, and slightly reduced activity. The effects of LB10522 on the hemodynamics and cardiac function of anesthetized beagle dogs are as follows; heart rates and mean arterial blood pressure had a tendency to increase mildly, which is a normal finding in anesthetized dogs. All the animals except for one showed relatively stable respiratory rates throughout the observation period. Each animal treated with LB10522 showed slight increase in the left cardiac work and left ventricular stroke work which are mainly related to corresponding increases in cardiac output. Femoral blood flow were shown to be increased in some animals treated with LB10522. The epileptogenic activities of various cephalosporins were assessed by a direct intracerebral injection of appropriate concentration of test articles. The CD values (nmol) obtained from the analysis of the dose-response data are as follows; 78.2, 175.3, 156.3, and 53.5 for cefazolin, cephaloridine, ceftazidime, and LB 10522, respectively. LB10522 seems to be equipotent with cefazolin or to be three times more potent than cephaloridine and ceftazidime in causing adverse CNS stimulation. Taken into consideration all the information obtained, LB10522 is not supposed to induce much changes in the functions examined in these studies in man at therapeutic doses.s." @default.
- W801469215 created "2016-06-24" @default.
- W801469215 creator A5006079429 @default.
- W801469215 creator A5051386861 @default.
- W801469215 creator A5056165726 @default.
- W801469215 creator A5060939029 @default.
- W801469215 creator A5080331900 @default.
- W801469215 date "1995-01-01" @default.
- W801469215 modified "2023-09-23" @default.
- W801469215 title "Safety Evaluation of LB10522, a New Cephalosporin Antibiotic" @default.
- W801469215 hasPublicationYear "1995" @default.
- W801469215 type Work @default.
- W801469215 sameAs 801469215 @default.
- W801469215 citedByCount "0" @default.
- W801469215 crossrefType "journal-article" @default.
- W801469215 hasAuthorship W801469215A5006079429 @default.
- W801469215 hasAuthorship W801469215A5051386861 @default.
- W801469215 hasAuthorship W801469215A5056165726 @default.
- W801469215 hasAuthorship W801469215A5060939029 @default.
- W801469215 hasAuthorship W801469215A5080331900 @default.
- W801469215 hasConcept C126322002 @default.
- W801469215 hasConcept C139940330 @default.
- W801469215 hasConcept C178853913 @default.
- W801469215 hasConcept C185592680 @default.
- W801469215 hasConcept C197934379 @default.
- W801469215 hasConcept C2776820430 @default.
- W801469215 hasConcept C2776968632 @default.
- W801469215 hasConcept C2777085960 @default.
- W801469215 hasConcept C2777457247 @default.
- W801469215 hasConcept C2777637488 @default.
- W801469215 hasConcept C2778353156 @default.
- W801469215 hasConcept C42219234 @default.
- W801469215 hasConcept C501593827 @default.
- W801469215 hasConcept C523546767 @default.
- W801469215 hasConcept C54355233 @default.
- W801469215 hasConcept C55493867 @default.
- W801469215 hasConcept C64778159 @default.
- W801469215 hasConcept C71924100 @default.
- W801469215 hasConcept C84393581 @default.
- W801469215 hasConcept C86803240 @default.
- W801469215 hasConcept C98274493 @default.
- W801469215 hasConceptScore W801469215C126322002 @default.
- W801469215 hasConceptScore W801469215C139940330 @default.
- W801469215 hasConceptScore W801469215C178853913 @default.
- W801469215 hasConceptScore W801469215C185592680 @default.
- W801469215 hasConceptScore W801469215C197934379 @default.
- W801469215 hasConceptScore W801469215C2776820430 @default.
- W801469215 hasConceptScore W801469215C2776968632 @default.
- W801469215 hasConceptScore W801469215C2777085960 @default.
- W801469215 hasConceptScore W801469215C2777457247 @default.
- W801469215 hasConceptScore W801469215C2777637488 @default.
- W801469215 hasConceptScore W801469215C2778353156 @default.
- W801469215 hasConceptScore W801469215C42219234 @default.
- W801469215 hasConceptScore W801469215C501593827 @default.
- W801469215 hasConceptScore W801469215C523546767 @default.
- W801469215 hasConceptScore W801469215C54355233 @default.
- W801469215 hasConceptScore W801469215C55493867 @default.
- W801469215 hasConceptScore W801469215C64778159 @default.
- W801469215 hasConceptScore W801469215C71924100 @default.
- W801469215 hasConceptScore W801469215C84393581 @default.
- W801469215 hasConceptScore W801469215C86803240 @default.
- W801469215 hasConceptScore W801469215C98274493 @default.
- W801469215 hasIssue "4" @default.
- W801469215 hasLocation W8014692151 @default.
- W801469215 hasOpenAccess W801469215 @default.
- W801469215 hasPrimaryLocation W8014692151 @default.
- W801469215 hasRelatedWork W174790316 @default.
- W801469215 hasRelatedWork W1960025380 @default.
- W801469215 hasRelatedWork W1970580604 @default.
- W801469215 hasRelatedWork W1973602943 @default.
- W801469215 hasRelatedWork W1995684844 @default.
- W801469215 hasRelatedWork W2011754787 @default.
- W801469215 hasRelatedWork W2023073968 @default.
- W801469215 hasRelatedWork W2034716378 @default.
- W801469215 hasRelatedWork W2049986100 @default.
- W801469215 hasRelatedWork W2085677692 @default.
- W801469215 hasRelatedWork W2119572830 @default.
- W801469215 hasRelatedWork W2152596553 @default.
- W801469215 hasRelatedWork W2214097603 @default.
- W801469215 hasRelatedWork W2274364184 @default.
- W801469215 hasRelatedWork W2323565043 @default.
- W801469215 hasRelatedWork W2353007215 @default.
- W801469215 hasRelatedWork W2402842299 @default.
- W801469215 hasRelatedWork W2513485489 @default.
- W801469215 hasRelatedWork W52098979 @default.
- W801469215 hasRelatedWork W1945489726 @default.
- W801469215 hasVolume "3" @default.
- W801469215 isParatext "false" @default.
- W801469215 isRetracted "false" @default.
- W801469215 magId "801469215" @default.
- W801469215 workType "article" @default.