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- W802329956 abstract "Coxsackieviruses, echoviruses, and polioviruses have been implicated in the pathogenesis of human neuromuscular diseases because o f their association with certain acute and chronic acquired myopathies and paralytic motor neuron syndromes. The advent of new molecular techniques has added to both the capability of establishing and the controversy surrounding the role of enteroviruses in various acquired inflammatory muscle diseases and motor neuron syndromes such as polymyositis (PM), dermatomyositis (DM), chronic fatigue syndrome (CFS), postpolio syndrome (PPS), and amyotrophic lateral sclerosis (ALS), each of which is discussed in this chapter. The author has studied muscle biopsy specimens from 39 patients (16 with PM, 12 with DM, and 11 with inclusion body myositis) who fulfilled the strict diagnostic clinicopathologic criteria of active inflammatory myopathy. Two recent studies using in situ hybridization, PCR, and sequence analysis of the amplified product have shown the presence of an enterovirus that differs from the typical strains in the 5' non coding region, suggesting a virus defective or mutated in that region. Biologic plausibility coupled with preliminary laboratory data has focused much attention on the enteroviruses as causative agents in numerous acute and chronic human muscle diseases." @default.
- W802329956 created "2016-06-24" @default.
- W802329956 creator A5090062651 @default.
- W802329956 date "2014-04-09" @default.
- W802329956 modified "2023-09-27" @default.
- W802329956 title "Enteroviruses and Human Neuromuscular Diseases" @default.
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- W802329956 doi "https://doi.org/10.1128/9781555818326.ch16" @default.
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