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- W8028636 abstract "This chapter focuses on the regulation of gene expression in mammalian cells. In mammalian tissues, in fact in most eukaryotic tissues, a recognized predominant action of cyclic AMP (cAMP) is the stimulation of enzymic phosphokinase activities that are responsible for the phosphorylation of proteins. It has been proposed that hormones that activate adenyl cyclase regulate gene activity via the cAMP promotion of histone phosphorylation, the latter permitting more efficient gene transcription than does its non-phosphorylated form. Many attempts have been made to demonstrate that hormones exert their effects on gene expression at the level of gene transcription, analogous to the action of inducers on the lactose operon in Escherichia coli. An integral part of the regulatory mechanisms in prokaryotes is the rapid turnover of messenger RNA molecules. Thus, when specific gene transcription is repressed, the concentration of specific RNA template rapidly falls and the synthesis of the specific protein ceases. Furthermore, the rate of specific protein synthesis is frequently determined only by the concentration of specific template RNA. Any system in which a paradoxical stimulation of specific protein synthesis is caused by inhibitors of RNA synthesis is quite likely to be subject to a posttranscriptional regulation of gene expression. Therefore, it may be that the posttranscriptional regulation of gene expression is a general mechanism found in many developing and inducible systems of eukaryotes." @default.
- W8028636 created "2016-06-24" @default.
- W8028636 creator A5056659794 @default.
- W8028636 date "1971-01-01" @default.
- W8028636 modified "2023-09-27" @default.
- W8028636 title "Regulation of Gene Expression in Mammalian Cells" @default.
- W8028636 cites W1490681781 @default.
- W8028636 cites W1491391587 @default.
- W8028636 cites W1503370943 @default.
- W8028636 cites W1505580050 @default.
- W8028636 cites W1519682167 @default.
- W8028636 cites W1532309638 @default.
- W8028636 cites W1565730309 @default.
- W8028636 cites W1575089413 @default.
- W8028636 cites W1576399086 @default.
- W8028636 cites W1596579902 @default.
- W8028636 cites W1648305906 @default.
- W8028636 cites W181520079 @default.
- W8028636 cites W1856530031 @default.
- W8028636 cites W1889990604 @default.
- W8028636 cites W1939022720 @default.
- W8028636 cites W194696711 @default.
- W8028636 cites W1964171318 @default.
- W8028636 cites W1964745067 @default.
- W8028636 cites W1966222075 @default.
- W8028636 cites W1967134681 @default.
- W8028636 cites W1982601116 @default.
- W8028636 cites W1982884505 @default.
- W8028636 cites W1983698852 @default.
- W8028636 cites W1984696016 @default.
- W8028636 cites W1990030779 @default.
- W8028636 cites W1994804727 @default.
- W8028636 cites W1998290353 @default.
- W8028636 cites W1998626141 @default.
- W8028636 cites W2000254851 @default.
- W8028636 cites W2003818827 @default.
- W8028636 cites W2007183273 @default.
- W8028636 cites W2007474046 @default.
- W8028636 cites W2008949082 @default.
- W8028636 cites W2013216313 @default.
- W8028636 cites W2013574886 @default.
- W8028636 cites W2014889718 @default.
- W8028636 cites W2015213501 @default.
- W8028636 cites W2023796599 @default.
- W8028636 cites W2023986404 @default.
- W8028636 cites W2024817429 @default.
- W8028636 cites W2029146706 @default.
- W8028636 cites W2031761184 @default.
- W8028636 cites W2032619610 @default.
- W8028636 cites W2034935596 @default.
- W8028636 cites W2038489221 @default.
- W8028636 cites W2041588538 @default.
- W8028636 cites W2041786979 @default.
- W8028636 cites W2043262229 @default.
- W8028636 cites W2043810017 @default.
- W8028636 cites W2045331059 @default.
- W8028636 cites W2047640436 @default.
- W8028636 cites W2048763338 @default.
- W8028636 cites W2049224937 @default.
- W8028636 cites W2050829260 @default.
- W8028636 cites W2051902336 @default.
- W8028636 cites W2056401491 @default.
- W8028636 cites W2056514569 @default.
- W8028636 cites W2056544004 @default.
- W8028636 cites W2059405289 @default.
- W8028636 cites W2060145765 @default.
- W8028636 cites W2061482652 @default.
- W8028636 cites W2070030282 @default.
- W8028636 cites W2075507370 @default.
- W8028636 cites W2076363664 @default.
- W8028636 cites W2076599825 @default.
- W8028636 cites W2080470330 @default.
- W8028636 cites W2084413158 @default.
- W8028636 cites W2084735219 @default.
- W8028636 cites W2085214862 @default.
- W8028636 cites W2086719435 @default.
- W8028636 cites W2092975262 @default.
- W8028636 cites W2097430264 @default.
- W8028636 cites W2108524524 @default.
- W8028636 cites W2116453093 @default.
- W8028636 cites W2118004344 @default.
- W8028636 cites W2123164383 @default.
- W8028636 cites W2124709411 @default.
- W8028636 cites W2127385301 @default.
- W8028636 cites W2129413541 @default.
- W8028636 cites W2134585740 @default.
- W8028636 cites W2142397154 @default.
- W8028636 cites W2155899304 @default.
- W8028636 cites W2313408830 @default.
- W8028636 cites W2324943702 @default.
- W8028636 cites W25041719 @default.
- W8028636 cites W3024876743 @default.
- W8028636 cites W3206570346 @default.
- W8028636 cites W1996902653 @default.
- W8028636 doi "https://doi.org/10.1016/b978-0-12-299255-1.50013-4" @default.
- W8028636 hasPublicationYear "1971" @default.
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