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- W80291824 endingPage "139" @default.
- W80291824 startingPage "117" @default.
- W80291824 abstract "Eukaryotic cells possess distinct and double-membrane encapsulated organelles, the mitochondria. The mitochondrion is the powerhouse of the cell responsible for energy production through oxidative phosphorylation. A dark side of the mitochondrion is its ability to generate reactive oxygen species (ROS) at specific sites of electron transport chain (ETC) arising from incomplete reduction of molecular oxygen. The mitochondrion is not only a source of toxic ROS but also their target and thus becomes vulnerable to oxidative attack. The ROS-mediated peroxidation of polyunsaturated fatty acids in mitochondrial membrane lipids leads to cell damage and injury of the tissue leading to pathophysiological states. The mitochondrial inner membrane that houses the ETC responsible for the cellular bioenergetics possesses a unique phospholipid, cardiolipin (CL), which is rich in polyunsaturated fatty acids susceptible to the ROS-induced peroxidation. Peroxidized CL has emerged as an important player in the mitochondria-driven oxidant lung injury, apoptotic cell death, and lung diseases. This review discusses the nature of the mitochondrial membrane lipids, mechanisms and consequences of the ROS-induced mitochondrial lipid peroxidation, and lipoperoxidative mechanisms of lung injury and diseases. Finally the pharmacological interventions of ROS-induced lung mitochondrial lipid peroxidation and mitochondriopathy that is involved in oxidant-induced lung damage and respiratory and lung diseases are also discussed." @default.
- W80291824 created "2016-06-24" @default.
- W80291824 creator A5000655349 @default.
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- W80291824 creator A5035375282 @default.
- W80291824 creator A5048118890 @default.
- W80291824 creator A5077660811 @default.
- W80291824 date "2014-01-01" @default.
- W80291824 modified "2023-10-16" @default.
- W80291824 title "Mitochondrial Lipid Peroxidation in Lung Damage and Disease" @default.
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