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• W803293519 abstract "Neuroblastoma (NB) is the most common and deadly extracranial solid tumor of childhood characterized by a resistance to chemotherapy possibly due to the presence of tumor initiating cells (TICs). Studies showed the role of CD133 as a marker of TICs in various types of cancers. Our goals were first to demonstrate the stemness of TICs expressing CD133 and then, using a global genomic analysis with single nucleotide polymorphism (SNPs), to perform a differential analysis between TICs and other cells of NB to identify the specific genetic abnormalities. NB cell lines were sorted by flow cytometry to obtain two populations: one enriched in CD133 (CD133), the other low in CD133 (CD133). To determine whether these cell populations have TICs properties, we test the ability of cells to form either neurospheres or, colonies in soft agar and we also test their carcinogenic properties by orthotopic injections of 500 selected cells in 11 mice. After a DNA extraction on selected populations, a differential genotyping analysis has been made with Affymetrix Genome-Wide Human SNP Array 6.0. To verify the expression of the genes identified, Western blots had been made. Our results have demonstrated that CD133 population presented TICs properties in vitro and in vivo. The differential genotyping analysis allowed identifying two gains common regions (16p13.3 and 19p13.3) in CD133 population and two others loss of heterozygosity (LOH) (16q12.1 and 21q21.3) in CD133 population . No losses were observed. Among the genes studied, ephrin-A2 protein expression was correlated to CD133 expression in 6 NB tumors and 2 NB cell lines. Also, ephrin-A2’s increased concentration influenced the neurospheres by decreasing their size. Thereby, CD133 population, which had TICs properties, possess different genotyping characteristics compared to CD133 population. The presence of ephrine-A2 in cells expressing CD133 emphasizes its importance in the development of TICs. These results suggest the presence of potential target for new therapies targeting the TICs demonstrated by the genomic study." @default.
• W803293519 created "2016-06-24" @default.
• W803293519 creator A5046028884 @default.
• W803293519 date "2012-04-05" @default.
• W803293519 modified "2023-09-27" @default.
• W803293519 title "Analyse génotypique des cellules initiatrices de tumeurs exprimant CD133 dans le neuroblastome" @default.
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