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- W80331471 abstract "Publisher Summary Diuretics and angiotensin-converting enzyme (ACE) inhibitors are commonly used in combination, both for patients with heart failure and for those with hypertension. Diuretics activate the rennin–angiotensin–aldosterone (RAAS) system that may limit the effects of diuretics on vascular tone and sodium excretion, which in turn, may limit their efficacy in reducing arterial pressure or in improving the symptoms of heart failure. ACE inhibitors can reduce plasma concentrations of angiotensin II and aldosterone, providing a theoretical rationale for use in combination with a diuretic. However, theoretical assumptions should always be tested. Clinical experiments in this field frequently have been unable to uphold theory, have sometimes contradicted it, and have occasionally revealed evidence for a more exciting interaction than predicted. Studies of hypertension confirm that ACE inhibitors enhance the antihypertensive effects of diuretics, though the interaction appears more additive than synergistic. Combining diuretics with ACE inhibitors appear to be no more effective than combining them with beta blockers. However, as diuretics may activate the sympathetic nervous system, as well as the RAAS, this cannot be taken as evidence that a neuroendocrine substrate for an ACE inhibitor/diuretic interaction does not exist." @default.
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- W80331471 date "1997-01-01" @default.
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- W80331471 title "Interactions between ACE Inhibitors and Diuretics" @default.
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- W80331471 doi "https://doi.org/10.1016/b978-012635690-8/50016-5" @default.
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