Matches in SemOpenAlex for { <https://semopenalex.org/work/W803329400> ?p ?o ?g. }
- W803329400 endingPage "3289" @default.
- W803329400 startingPage "3285" @default.
- W803329400 abstract "We synthesized a series of novel 5-24 derivatives of oxindole. The synthesis started from 5-chlorooxindole, which was condensed with methyl 4-carboxybezoate and result in the formation of benzolyester derivatives of oxindole which was then treated with hydrazine hydrate. The oxindole benzoylhydrazide was treated with aryl acetophenones and aldehydes to get target compounds 5-24. The synthesized compounds were evaluated for urease inhibition; the compound 5 (IC50 = 13.00 ± 0.35 μM) and 11 (IC50 = 19.20 ± 0.50 μM) showed potent activity as compared to the standard drug thiourea (IC50 = 21.00 ± 0.01 μM). Other compounds showed moderate to weak activity. All synthetic compounds were characterized by different spectroscopic techniques including (1)H NMR, (13)C NMR, IR and EI MS. The molecular interactions of the active compounds within the binding site of urease enzyme were studied through molecular docking simulations." @default.
- W803329400 created "2016-06-24" @default.
- W803329400 creator A5021049882 @default.
- W803329400 creator A5023610691 @default.
- W803329400 creator A5032226045 @default.
- W803329400 creator A5038073334 @default.
- W803329400 creator A5050202051 @default.
- W803329400 creator A5062086684 @default.
- W803329400 creator A5064723726 @default.
- W803329400 creator A5078032577 @default.
- W803329400 creator A5086422606 @default.
- W803329400 creator A5091778180 @default.
- W803329400 date "2015-08-01" @default.
- W803329400 modified "2023-09-27" @default.
- W803329400 title "Synthesis of novel derivatives of oxindole, their urease inhibition and molecular docking studies" @default.
- W803329400 cites W1912217738 @default.
- W803329400 cites W1973388799 @default.
- W803329400 cites W1977011380 @default.
- W803329400 cites W1981737096 @default.
- W803329400 cites W1983051748 @default.
- W803329400 cites W1988805785 @default.
- W803329400 cites W1989209531 @default.
- W803329400 cites W2008043980 @default.
- W803329400 cites W2013778864 @default.
- W803329400 cites W2016403352 @default.
- W803329400 cites W2022761153 @default.
- W803329400 cites W2029082748 @default.
- W803329400 cites W2035874030 @default.
- W803329400 cites W2038430270 @default.
- W803329400 cites W2039619503 @default.
- W803329400 cites W2042219247 @default.
- W803329400 cites W2046479408 @default.
- W803329400 cites W2046588215 @default.
- W803329400 cites W2050282962 @default.
- W803329400 cites W2057903963 @default.
- W803329400 cites W2064074738 @default.
- W803329400 cites W2078122867 @default.
- W803329400 cites W2086956415 @default.
- W803329400 cites W2093479140 @default.
- W803329400 cites W2099930536 @default.
- W803329400 cites W2104268626 @default.
- W803329400 cites W2120924294 @default.
- W803329400 cites W2131109213 @default.
- W803329400 cites W2132674303 @default.
- W803329400 cites W2140817750 @default.
- W803329400 cites W2145130007 @default.
- W803329400 cites W2149302140 @default.
- W803329400 cites W2150458632 @default.
- W803329400 cites W2162061482 @default.
- W803329400 cites W2179642533 @default.
- W803329400 cites W2367811897 @default.
- W803329400 cites W4242372416 @default.
- W803329400 cites W4249760299 @default.
- W803329400 doi "https://doi.org/10.1016/j.bmcl.2015.05.069" @default.
- W803329400 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26077497" @default.
- W803329400 hasPublicationYear "2015" @default.
- W803329400 type Work @default.
- W803329400 sameAs 803329400 @default.
- W803329400 citedByCount "76" @default.
- W803329400 countsByYear W8033294002015 @default.
- W803329400 countsByYear W8033294002016 @default.
- W803329400 countsByYear W8033294002017 @default.
- W803329400 countsByYear W8033294002018 @default.
- W803329400 countsByYear W8033294002019 @default.
- W803329400 countsByYear W8033294002020 @default.
- W803329400 countsByYear W8033294002021 @default.
- W803329400 countsByYear W8033294002022 @default.
- W803329400 countsByYear W8033294002023 @default.
- W803329400 crossrefType "journal-article" @default.
- W803329400 hasAuthorship W803329400A5021049882 @default.
- W803329400 hasAuthorship W803329400A5023610691 @default.
- W803329400 hasAuthorship W803329400A5032226045 @default.
- W803329400 hasAuthorship W803329400A5038073334 @default.
- W803329400 hasAuthorship W803329400A5050202051 @default.
- W803329400 hasAuthorship W803329400A5062086684 @default.
- W803329400 hasAuthorship W803329400A5064723726 @default.
- W803329400 hasAuthorship W803329400A5078032577 @default.
- W803329400 hasAuthorship W803329400A5086422606 @default.
- W803329400 hasAuthorship W803329400A5091778180 @default.
- W803329400 hasConcept C159110408 @default.
- W803329400 hasConcept C161790260 @default.
- W803329400 hasConcept C178790620 @default.
- W803329400 hasConcept C181199279 @default.
- W803329400 hasConcept C185592680 @default.
- W803329400 hasConcept C21951064 @default.
- W803329400 hasConcept C2776597398 @default.
- W803329400 hasConcept C2779521917 @default.
- W803329400 hasConcept C2780083155 @default.
- W803329400 hasConcept C2780263894 @default.
- W803329400 hasConcept C2780538656 @default.
- W803329400 hasConcept C2781060337 @default.
- W803329400 hasConcept C2781076698 @default.
- W803329400 hasConcept C41685203 @default.
- W803329400 hasConcept C55493867 @default.
- W803329400 hasConcept C71240020 @default.
- W803329400 hasConcept C71924100 @default.
- W803329400 hasConceptScore W803329400C159110408 @default.
- W803329400 hasConceptScore W803329400C161790260 @default.