Matches in SemOpenAlex for { <https://semopenalex.org/work/W803479915> ?p ?o ?g. }
- W803479915 endingPage "e0130587" @default.
- W803479915 startingPage "e0130587" @default.
- W803479915 abstract "Atherosclerosis, the major pathology of cardiovascular disease, is caused by multiple factors involving psychological stress. Corticotropin-releasing hormone (CRH), which is released by neurosecretory cells in the hypothalamus, peripheral nerve terminals and epithelial cells, regulates various stress-related responses. Our current study aimed to verify the role of CRH in macrophage foam cell formation, the initial critical stage of atherosclerosis. Our quantitative real-time reverse transcriptase PCR (qRT-PCR), semi-quantitative reverse transcriptase PCR, and Western blot results indicate that CRH down-regulates ATP-binding cassette transporter-1 (ABCA1) and liver X receptor (LXR)-α, a transcription factor for ABCA1, in murine peritoneal macrophages and human monocyte-derived macrophages. Oil-red O (ORO) staining and intracellular cholesterol measurement of macrophages treated with or without oxidized LDL (oxLDL) and with or without CRH (10 nM) in the presence of apolipoprotein A1 (apoA1) revealed that CRH treatment promotes macrophage foam cell formation. The boron-dipyrromethene (BODIPY)-conjugated cholesterol efflux assay showed that CRH treatment reduces macrophage cholesterol efflux. Western blot analysis showed that CRH-induced down-regulation of ABCA1 is dependent on phosphorylation of Akt (Ser473) induced by interaction between CRH and CRH receptor 1(CRHR1). We conclude that activation of this pathway by CRH accelerates macrophage foam cell formation and may promote stress-related atherosclerosis." @default.
- W803479915 created "2016-06-24" @default.
- W803479915 creator A5024738648 @default.
- W803479915 creator A5030740700 @default.
- W803479915 creator A5051430071 @default.
- W803479915 date "2015-06-25" @default.
- W803479915 modified "2023-10-16" @default.
- W803479915 title "Corticotropin-Releasing Hormone (CRH) Promotes Macrophage Foam Cell Formation via Reduced Expression of ATP Binding Cassette Transporter-1 (ABCA1)" @default.
- W803479915 cites W1512559452 @default.
- W803479915 cites W1566592255 @default.
- W803479915 cites W1580532947 @default.
- W803479915 cites W1614065776 @default.
- W803479915 cites W1622987172 @default.
- W803479915 cites W1650965741 @default.
- W803479915 cites W1800953229 @default.
- W803479915 cites W1891002144 @default.
- W803479915 cites W1964844389 @default.
- W803479915 cites W1967734914 @default.
- W803479915 cites W1971504559 @default.
- W803479915 cites W1972949410 @default.
- W803479915 cites W1979169145 @default.
- W803479915 cites W1988054781 @default.
- W803479915 cites W1989390730 @default.
- W803479915 cites W1990862560 @default.
- W803479915 cites W1994378299 @default.
- W803479915 cites W2000185732 @default.
- W803479915 cites W2006955905 @default.
- W803479915 cites W2014939804 @default.
- W803479915 cites W2015805615 @default.
- W803479915 cites W2016345051 @default.
- W803479915 cites W2016856943 @default.
- W803479915 cites W2019823288 @default.
- W803479915 cites W2021098104 @default.
- W803479915 cites W2021430553 @default.
- W803479915 cites W2022986947 @default.
- W803479915 cites W2023369448 @default.
- W803479915 cites W2036979192 @default.
- W803479915 cites W2037261229 @default.
- W803479915 cites W2044413542 @default.
- W803479915 cites W2046752054 @default.
- W803479915 cites W2049064718 @default.
- W803479915 cites W2059848118 @default.
- W803479915 cites W2074277484 @default.
- W803479915 cites W2077629284 @default.
- W803479915 cites W2088218868 @default.
- W803479915 cites W2093296161 @default.
- W803479915 cites W2095153977 @default.
- W803479915 cites W2097061706 @default.
- W803479915 cites W2099632438 @default.
- W803479915 cites W2102495825 @default.
- W803479915 cites W2104799574 @default.
- W803479915 cites W2105923985 @default.
- W803479915 cites W2114894040 @default.
- W803479915 cites W2116005889 @default.
- W803479915 cites W2116629441 @default.
- W803479915 cites W2116920483 @default.
- W803479915 cites W2117672006 @default.
- W803479915 cites W2119183597 @default.
- W803479915 cites W2121076428 @default.
- W803479915 cites W2137138317 @default.
- W803479915 cites W2154760725 @default.
- W803479915 cites W2161369618 @default.
- W803479915 cites W2168699761 @default.
- W803479915 cites W2170417134 @default.
- W803479915 cites W2170535838 @default.
- W803479915 cites W2219724094 @default.
- W803479915 cites W2342901117 @default.
- W803479915 cites W4233455462 @default.
- W803479915 doi "https://doi.org/10.1371/journal.pone.0130587" @default.
- W803479915 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4481410" @default.
- W803479915 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26110874" @default.
- W803479915 hasPublicationYear "2015" @default.
- W803479915 type Work @default.
- W803479915 sameAs 803479915 @default.
- W803479915 citedByCount "11" @default.
- W803479915 countsByYear W8034799152016 @default.
- W803479915 countsByYear W8034799152017 @default.
- W803479915 countsByYear W8034799152018 @default.
- W803479915 countsByYear W8034799152019 @default.
- W803479915 countsByYear W8034799152020 @default.
- W803479915 countsByYear W8034799152021 @default.
- W803479915 countsByYear W8034799152022 @default.
- W803479915 countsByYear W8034799152023 @default.
- W803479915 crossrefType "journal-article" @default.
- W803479915 hasAuthorship W803479915A5024738648 @default.
- W803479915 hasAuthorship W803479915A5030740700 @default.
- W803479915 hasAuthorship W803479915A5051430071 @default.
- W803479915 hasBestOaLocation W8034799151 @default.
- W803479915 hasConcept C104317684 @default.
- W803479915 hasConcept C126322002 @default.
- W803479915 hasConcept C134018914 @default.
- W803479915 hasConcept C149011108 @default.
- W803479915 hasConcept C185592680 @default.
- W803479915 hasConcept C202751555 @default.
- W803479915 hasConcept C2776415932 @default.
- W803479915 hasConcept C2777704780 @default.
- W803479915 hasConcept C2777895019 @default.
- W803479915 hasConcept C2778163477 @default.