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- W80410769 abstract "Publisher Summary This chapter discusses H-2 restriction of T-cell function phenomenon. H-2 restriction of target cell lysis has also been observed in cytolysis by T cells sensitized to minor histocompatibility antigens, haptenic determinants, and Y antigens. H-2 products have also been found to restrict reactivity of T cells mediating delayed hypersensitivity to soluble antigens of helper T cells involved in the humoral immune response and of T cells that proliferate in response to antigen pulsed macrophages. The phenomenon of H-2 restriction of cell mediated cytotoxicity was first reported by Zinkernagel and Doherty. Subsequent experiments demonstrate that immunization of Fl mice with LCM virus results in the generation of at least two subpopulations of cytotoxic T cells, each of which is specifically lytic for target cells expressing one of the two parental H-2 haplotypes. The physiological interaction model is also incompatible with a number of studies demonstrating that H restriction of cytotoxicity is not limited to syngeneic determinants. Recently, a third theory has been proposed to explain H-2 restriction of T cell activity. According to this model, cytotoxic T cell precursors possess two antigen receptor systems." @default.
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- W80410769 date "1977-01-01" @default.
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- W80410769 title "WORKSHOP ON H-2 RESTRICTION OF T CELL FUNCTION" @default.
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- W80410769 doi "https://doi.org/10.1016/b978-0-12-458050-3.50053-9" @default.
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