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- W8043290 endingPage "652" @default.
- W8043290 startingPage "623" @default.
- W8043290 abstract "The greatest merit of in vivo magnetic resonance spectroscopy (MRS) methodology used in brain research is its ability to noninvasively determine cerebral metabolites, metabolic rates and their dynamic changes caused by physiological or pathological perturbations. The utility of in vivo MRS is further enhanced with high/ultrahigh magnetic field strength instruments because of significant gains in detection sensitivity and improvements in spectral resolution. Recent progress of in vivo 31P and 17O MRS methodologies at high field has further demonstrated great potential and promise for in vivo measurements of crucial metabolic rates with regard to two essential chemical processes: cerebral oxygen utilization and oxidative phosphorylation of ADP. These metabolic rates are tightly linked to each other and are ultimately regulated by ATP consumption. This chapter provides a brief review of the new developments in in vivo 31P and 17O MRS techniques and their applications to the study of cerebral oxidative metabolism in supporting brain activity and function." @default.
- W8043290 created "2016-06-24" @default.
- W8043290 creator A5017541508 @default.
- W8043290 creator A5072179623 @default.
- W8043290 date "2011-12-17" @default.
- W8043290 modified "2023-09-26" @default.
- W8043290 title "In Vivo Studies of Brain Oxygen Metabolism and Oxidative Phosphorylation" @default.
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