FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W8045798> ?p ?o ?g. }

• W8045798 endingPage "117" @default.
• W8045798 startingPage "106" @default.
• W8045798 abstract "<i>Background and Relevance:</i> Atherosclerotic stenosis of the major intracranial arteries is an important cause of transient ischemic attack (TIA) or stroke. Of the 900,000 patients who suffer a TIA or stroke each year in the USA, intracranial stenosis is responsible for approximately 10%, i.e. 90,000 patients. There have been no prospective trials evaluating antithrombotic therapies for preventing recurrent vascular events in these patients. The main objective of this trial is to compare warfarin [International Normalized Ratio (INR) 2–3] with aspirin (1,300 mg/day) for preventing stroke (ischemic and hemorrhagic) and vascular death in patients presenting with TIA or stroke caused by stenosis of a major intracranial artery. <i>Study Design:</i> Prospective, randomized, double-blind, multicenter trial. The sample size<i></i>required will be 403 patients per group, based on stroke and vascular death rates of 33% per 3 years in the aspirin group vs. 22% per 3 years in the warfarin group, a p value of 0.05, power of 80%, a 24% rate of ‘withdrawal of therapy’, and a 1% rate of ‘lost to follow-up’. <i>Conduct of Trial:</i> Patients with TIA or nondisabling stroke caused by ≧50% stenosis of a major intracranial artery documented by catheter angiography are randomized to warfarin or aspirin. Patients are contacted monthly by phone and examined every 4 months until a common termination date. Mean follow-up in the study is expected to be 3 years. <i>Conclusion:</i> This study will determine whether warfarin or aspirin is superior for patients with symptomatic intracranial arterial stenosis. Furthermore, it will identify patients whose rate of ischemic stroke in the territory of the stenotic intracranial artery on best medical therapy is sufficiently high to justify a subsequent trial comparing intracranial angioplasty/stenting with best medical therapy in this subset of patients." @default.
• W8045798 created "2016-06-24" @default.
• W8045798 creator A5000498350 @default.
• W8045798 creator A5001425519 @default.
• W8045798 creator A5001863831 @default.
• W8045798 creator A5003324617 @default.
• W8045798 creator A5003389533 @default.
• W8045798 creator A5004974136 @default.
• W8045798 creator A5007119814 @default.
• W8045798 creator A5007746022 @default.
• W8045798 creator A5008513987 @default.
• W8045798 creator A5009170752 @default.
• W8045798 creator A5010124625 @default.
• W8045798 creator A5011832099 @default.
• W8045798 creator A5011894087 @default.
• W8045798 creator A5012053598 @default.
• W8045798 creator A5012872303 @default.
• W8045798 creator A5013982836 @default.
• W8045798 creator A5015792922 @default.
• W8045798 creator A5018260212 @default.
• W8045798 creator A5018625045 @default.
• W8045798 creator A5018986111 @default.
• W8045798 creator A5019914929 @default.
• W8045798 creator A5020743917 @default.
• W8045798 creator A5021735961 @default.
• W8045798 creator A5022687921 @default.
• W8045798 creator A5022823811 @default.
• W8045798 creator A5024815763 @default.
• W8045798 creator A5025673809 @default.
• W8045798 creator A5026974312 @default.
• W8045798 creator A5027213180 @default.
• W8045798 creator A5027551291 @default.
• W8045798 creator A5027698455 @default.
• W8045798 creator A5028418445 @default.
• W8045798 creator A5029401183 @default.
• W8045798 creator A5030910492 @default.
• W8045798 creator A5031709626 @default.
• W8045798 creator A5033302533 @default.
• W8045798 creator A5033941273 @default.
• W8045798 creator A5033945043 @default.
• W8045798 creator A5035503064 @default.
• W8045798 creator A5039699849 @default.
• W8045798 creator A5039781589 @default.
• W8045798 creator A5041401383 @default.
• W8045798 creator A5041750250 @default.
• W8045798 creator A5041769434 @default.
• W8045798 creator A5041948975 @default.
• W8045798 creator A5042671764 @default.
• W8045798 creator A5042819749 @default.
• W8045798 creator A5043183985 @default.
• W8045798 creator A5043521838 @default.
• W8045798 creator A5048268798 @default.
• W8045798 creator A5048763865 @default.
• W8045798 creator A5048952504 @default.
• W8045798 creator A5049673596 @default.
• W8045798 creator A5049838155 @default.
• W8045798 creator A5050191315 @default.
• W8045798 creator A5051252423 @default.
• W8045798 creator A5052056741 @default.
• W8045798 creator A5052141022 @default.
• W8045798 creator A5052711559 @default.
• W8045798 creator A5052993534 @default.
• W8045798 creator A5053120888 @default.
• W8045798 creator A5055168814 @default.
• W8045798 creator A5056794015 @default.
• W8045798 creator A5057361090 @default.
• W8045798 creator A5057590941 @default.
• W8045798 creator A5057809355 @default.
• W8045798 creator A5058684720 @default.
• W8045798 creator A5060157223 @default.
• W8045798 creator A5060550178 @default.
• W8045798 creator A5064063695 @default.
• W8045798 creator A5064413750 @default.
• W8045798 creator A5064866721 @default.
• W8045798 creator A5066008903 @default.
• W8045798 creator A5067254785 @default.
• W8045798 creator A5067843313 @default.
• W8045798 creator A5068081453 @default.
• W8045798 creator A5068086343 @default.
• W8045798 creator A5069890731 @default.
• W8045798 creator A5071189943 @default.
• W8045798 creator A5072106905 @default.
• W8045798 creator A5073032160 @default.
• W8045798 creator A5073374266 @default.
• W8045798 creator A5074580919 @default.
• W8045798 creator A5075227610 @default.
• W8045798 creator A5075257514 @default.
• W8045798 creator A5076573773 @default.
• W8045798 creator A5077101946 @default.
• W8045798 creator A5078480113 @default.
• W8045798 creator A5078687726 @default.
• W8045798 creator A5081062943 @default.
• W8045798 creator A5081874460 @default.
• W8045798 creator A5083980876 @default.
• W8045798 creator A5084245610 @default.
• W8045798 creator A5086474167 @default.
• W8045798 creator A5086609118 @default.
• W8045798 creator A5088689879 @default.

• next