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- W804770977 abstract "The aim of this study was to assess the infl uence of agmatine (AGM - an endogenous neuromodulator / neurotransmitter in the brain) on the protective action of two antiepileptic drugs (clobazam (CLB) and pregabalin (PGB)) in the mouse maximal electroshock seizure (MES) model. Results indicate that AGM at a dose of 100 mg/kg, i.p., 45 min before the test had no signifi cant eff ect on the anticonvulsant action of CLB or PGB in the MES test in mice. Moreover, the examined combination of AGM with CLB and PGB (at doses from the MES test) did not aff ect motor coordination in the chimney test and muscular strength in the grip-strength test in mice, indicating no acute adverse eff ects in animals. Based on the results from this study, it can be concluded that the lack of eff ect of AGM on the anti-convulsant action of CLB and PGB in the mouse MES model associated with no acute adverse eff ects in animals, make the combinations of AGM with CLB and PGB neutral from a preclinical point of view." @default.
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- W804770977 date "2010-06-30" @default.
- W804770977 modified "2023-09-26" @default.
- W804770977 title "No effect of agmatine on the protective activity of clobazam and pregabalin against maximal electroshock-induced seizures in mice" @default.
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