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- W804946231 abstract "In order to understand the structure of real structure spaces, we are studying the 5S rRNA structure space experimentally. A plasmid containing a synthetic 5S rRNA gene, two rRNA promoters, and transcription terminators has been assembled. Assays are conducted to determine if the foreign 5S rRNA is expressed, and to see whether or not it is incorporated into ribosomes. Evolutionary competition is used to determine the relative fitness of strains containing the foreign 5S rRNA and a control 5S rRNA. By using site directed mutagenesis, a number of mutants can be made in order to study the boundaries of the structure space and how sharply defined they are. By making similar studies in the vicinity of structure space, it will be possible to determine how homogeneous the 5S rRNA structure space is. Useable experimental protocols have been developed, and a number of mutants have already been studied. Initial results suggest an explanation of why single stranded regions of the RNA are less subject to mutation than double stranded regions." @default.
- W804946231 created "2016-06-24" @default.
- W804946231 creator A5058894543 @default.
- W804946231 date "1991-10-01" @default.
- W804946231 modified "2023-09-27" @default.
- W804946231 title "Exploration of RNA structure spaces" @default.
- W804946231 hasPublicationYear "1991" @default.
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