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• W80496550 abstract "Abstract The concept that cutaneous melanoma- (CM) in man is caused by ultraviolet (UV) radiation (the carcinogenic component of sunlight) is supported by latitudinal gradients in the incidence and the correlation to UV-related risk factors. As stratospheric ozone filters solar UV radiation, a reduction could lead to an increase in the incidence of CM. From the latitude-related UV gradient one finds that a 10% reduction in ozone would lead to approximately 5-20% more CMs in the white population in the USA. The epidemiologic data are, however, not entirely consistent with respect to the involvement of UV radiation. And epidemiological correlations by themselves can never establish a causal relationship. An experimental model to prove the possibility of such a causal relationship between CM and UV radiation is currently lacking. Differences in histogenetic types and/or locations on the body are often disregarded. There are indications that these kinds of distinctions may be important for a proper understanding of the etiology of CM. It has to be concluded that it is still conjectural to use a UV-related gradient in CM to assess the effect of an ozone reduction on the incidence of CM. A better understanding of the etiology of CM is mandatory." @default.
• W80496550 created "2016-06-24" @default.
• W80496550 creator A5019483239 @default.
• W80496550 date "1989-01-01" @default.
• W80496550 modified "2023-09-27" @default.
• W80496550 title "Ozonb Change and Melanoma" @default.
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• W80496550 doi "https://doi.org/10.1016/s0166-1116(08)70645-9" @default.
• W80496550 hasPublicationYear "1989" @default.
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