FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W80512758> ?p ?o ?g. }

• W80512758 endingPage "6" @default.
• W80512758 startingPage "81" @default.
• W80512758 abstract "Tuberculosis is treated with a group of drugs that need to be used over a long period of time and isoniazid is the major drug in this group. Antituberculosis drug-induced hepatitis is the most serious problem in tuberculosis treatment. The enzyme N-acetyltransferase-2 (NAT-2) metabolizes isoniazid in the liver so it is considered to cause hepatotoxicity. The association of polymorphic NAT acetylator status and antituberculosis drug-induced hepatitis is discussed. To determine whether acetylator status is a risk factor for antituberculosis drug-induced hepatitis, we genotyped NAT2*5A, NAT2*6A, NAT2*7A/B and NAT2*14A polymorphisms in 100 patients diagnosed with tuberculosis. 70 patients who did not develop hepatotoxicity were classified as the control group, and 30 patients who were diagnosed with antituberculosis drug-induced hepatitis were classified as the study group. NAT2 polymorphisms were divided into three phenotypic groups according to the analytical results obtained. Among the 70 patients constituting the control group; 14 (20%), 37 (52.9%), 19 (27.10%) patients were rapid, intermediate and slow acetylators respectively. In contrast, among the patients constituting the study group; 3 (10%), 4 (13.3%), 23 (76.7%) patients were rapid, intermediate and slow acetylators. The difference was statistically significant when the control and study groups were compared for their acetylator status. The proportion of slow acetylators was much higher in the study group. In conclusion, NAT2 acetylator phenotype analysis by molecular biology methods prior to medical treatment for tuberculosis, can be used both for determining the high-risk group of patients who may develop hepatotoxicity and for closer follow-up during treatment period." @default.
• W80512758 created "2016-06-24" @default.
• W80512758 creator A5003174653 @default.
• W80512758 creator A5011003739 @default.
• W80512758 creator A5031016273 @default.
• W80512758 creator A5045976340 @default.
• W80512758 creator A5047058047 @default.
• W80512758 creator A5063270587 @default.
• W80512758 creator A5085455972 @default.
• W80512758 date "2008-01-01" @default.
• W80512758 modified "2023-10-17" @default.
• W80512758 title "Determining the relation between N-acetyltransferase-2 acetylator phenotype and antituberculosis drug induced hepatitis by molecular biologic tests." @default.
• W80512758 cites W1687548251 @default.
• W80512758 cites W1690884721 @default.
• W80512758 cites W1970770917 @default.
• W80512758 cites W2003168515 @default.
• W80512758 cites W2011870475 @default.
• W80512758 cites W2044395372 @default.
• W80512758 cites W2154665816 @default.
• W80512758 cites W63257573 @default.
• W80512758 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18330759" @default.
• W80512758 hasPublicationYear "2008" @default.
• W80512758 type Work @default.
• W80512758 sameAs 80512758 @default.
• W80512758 citedByCount "11" @default.
• W80512758 countsByYear W805127582012 @default.
• W80512758 countsByYear W805127582013 @default.
• W80512758 countsByYear W805127582014 @default.
• W80512758 countsByYear W805127582015 @default.
• W80512758 countsByYear W805127582016 @default.
• W80512758 countsByYear W805127582017 @default.
• W80512758 countsByYear W805127582019 @default.
• W80512758 crossrefType "journal-article" @default.
• W80512758 hasAuthorship W80512758A5003174653 @default.
• W80512758 hasAuthorship W80512758A5011003739 @default.
• W80512758 hasAuthorship W80512758A5031016273 @default.
• W80512758 hasAuthorship W80512758A5045976340 @default.
• W80512758 hasAuthorship W80512758A5047058047 @default.
• W80512758 hasAuthorship W80512758A5063270587 @default.
• W80512758 hasAuthorship W80512758A5085455972 @default.
• W80512758 hasConcept C104317684 @default.
• W80512758 hasConcept C126322002 @default.
• W80512758 hasConcept C135763542 @default.
• W80512758 hasConcept C142724271 @default.
• W80512758 hasConcept C203014093 @default.
• W80512758 hasConcept C2776029263 @default.
• W80512758 hasConcept C2776967927 @default.
• W80512758 hasConcept C2777382497 @default.
• W80512758 hasConcept C2778328694 @default.
• W80512758 hasConcept C2780035454 @default.
• W80512758 hasConcept C2781069245 @default.
• W80512758 hasConcept C54355233 @default.
• W80512758 hasConcept C71924100 @default.
• W80512758 hasConcept C86803240 @default.
• W80512758 hasConcept C90924648 @default.
• W80512758 hasConcept C98274493 @default.
• W80512758 hasConceptScore W80512758C104317684 @default.
• W80512758 hasConceptScore W80512758C126322002 @default.
• W80512758 hasConceptScore W80512758C135763542 @default.
• W80512758 hasConceptScore W80512758C142724271 @default.
• W80512758 hasConceptScore W80512758C203014093 @default.
• W80512758 hasConceptScore W80512758C2776029263 @default.
• W80512758 hasConceptScore W80512758C2776967927 @default.
• W80512758 hasConceptScore W80512758C2777382497 @default.
• W80512758 hasConceptScore W80512758C2778328694 @default.
• W80512758 hasConceptScore W80512758C2780035454 @default.
• W80512758 hasConceptScore W80512758C2781069245 @default.
• W80512758 hasConceptScore W80512758C54355233 @default.
• W80512758 hasConceptScore W80512758C71924100 @default.
• W80512758 hasConceptScore W80512758C86803240 @default.
• W80512758 hasConceptScore W80512758C90924648 @default.
• W80512758 hasConceptScore W80512758C98274493 @default.
• W80512758 hasIssue "1" @default.
• W80512758 hasLocation W805127581 @default.
• W80512758 hasOpenAccess W80512758 @default.
• W80512758 hasPrimaryLocation W805127581 @default.
• W80512758 hasRelatedWork W108422455 @default.
• W80512758 hasRelatedWork W152971024 @default.
• W80512758 hasRelatedWork W1796807348 @default.
• W80512758 hasRelatedWork W1897159074 @default.
• W80512758 hasRelatedWork W1991366313 @default.
• W80512758 hasRelatedWork W2018201119 @default.
• W80512758 hasRelatedWork W2019740385 @default.
• W80512758 hasRelatedWork W2020976497 @default.
• W80512758 hasRelatedWork W2031834826 @default.
• W80512758 hasRelatedWork W2032322593 @default.
• W80512758 hasRelatedWork W2039895358 @default.
• W80512758 hasRelatedWork W2069830104 @default.
• W80512758 hasRelatedWork W2080211164 @default.
• W80512758 hasRelatedWork W2095134596 @default.
• W80512758 hasRelatedWork W2110418084 @default.
• W80512758 hasRelatedWork W2137840448 @default.
• W80512758 hasRelatedWork W2153043128 @default.
• W80512758 hasRelatedWork W2159445805 @default.
• W80512758 hasRelatedWork W2166822423 @default.
• W80512758 hasRelatedWork W95655410 @default.
• W80512758 hasVolume "56" @default.
• W80512758 isParatext "false" @default.

• next