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• W80515061 abstract "Enterotoxigenic (Escherichia) (coli) (ETEC) is a major cause of traveller’s and infantile diarrhoea in developing countries, and results in considerable mortality in under 5 year olds. Disease is mediated through adhesion of ETEC cells to the intestinal brush border and the secretion of the heat-stable and/or heat-labile toxin. Whilst the toxins have been well studied it is still not clear how their expression is regulated.This work has defined binding of CRP, H-NS and σ(^7)(^0) across the genome of the prototypical ETEC strain H10407. We demonstrate a central role for all three factors in regulating pathogenicity in ETEC H10407. Hence, we show that CRP directly regulates expression of both (estA2) and (estA1), which encode the heat-stable toxins. Furthermore, CRP indirectly represses expression of the heat-labile toxin. This work also identifies a role for CRP in controlling transcription of a small open reading frame, imbedded within a gene, at the 3’ end of an operon encoding a type I secretion system." @default.
• W80515061 created "2016-06-24" @default.
• W80515061 creator A5010362880 @default.
• W80515061 date "2015-07-01" @default.
• W80515061 modified "2023-09-24" @default.
• W80515061 title "Regulating expression of virulence determinants in enterotoxigenic escherichia coli H10407" @default.
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• W80515061 hasPublicationYear "2015" @default.
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