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- W8054311 abstract "In this study, we estimated permeability ratio (PNa/PCl) between Na and Cl for paracellular pathways of primary rat alveolar epithelial cell monolayers (RAECM). PNa/PCl was estimated using Goldman-Hodgkin-Katz equation and DP measured across RAECM at 5–7 days. To inhibit Na pump activities, RAECM were bathed on both sides with K-free Ringer's solution (KFRS, in which 5 mM KCl is replaced by equimolar NaCl). DP was measured after lowering apical [NaCl] tenfold by replacing apical fluid with a 9:1 mixture of isotonic K-free mannitol solution and KFRS. Osmolarity of all solutions was adjusted to 300 mOsm with mannitol. DP was further corrected for liquid junction potential of voltage-sensing electrodes across blank filters. Results show that equivalent short-circuit current across RAECM bathed on both sides with KFRS is not significantly different from zero with electrical resistance >1,000 Ωcm2. When apical [NaCl] was lowered tenfold, corrected DP ∼ −13 mV (apical as reference) was observed, yielding PNa/PCl ∼1.8. For comparison, the free solution diffusivity ratio of Na to Cl is ∼0.7, while paracellular PNa/PCl of various epithelial barriers ranges from ∼0.2 and ∼0.5 for frog skin and bullfrog lung to ∼1.3 and ∼10 for rabbit proximal tubule and rat jejunum, respectively. These data indicate that passive ion conductance through tight junctions of RAECM is greater for Na than Cl. (Support: NIH and Hastings Foundation.)" @default.
- W8054311 created "2016-06-24" @default.
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- W8054311 date "2008-03-01" @default.
- W8054311 modified "2023-09-24" @default.
- W8054311 title "Dilution potential (DP) across rat alveolar epithelial cell monolayers" @default.
- W8054311 doi "https://doi.org/10.1096/fasebj.22.1_supplement.932.2" @default.
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