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- W805741100 abstract "Abstract Assembly of a bipolar microtubule spindle is essential for accurate chromosome segregation. In somatic cells, spindle bipolarity is determined by the presence of exactly two centrosomes. Remarkably, mammalian oocytes do not contain canonical centrosomes. This study reveals that mouse oocytes assemble a bipolar spindle by fragmenting multiple acentriolar microtubule-organizing centres (MTOCs) into a high number of small MTOCs to be able to then regroup and merge them into two equal spindle poles. We show that MTOCs are fragmented in a three-step process. First, PLK1 triggers a decondensation of the MTOC structure. Second, BicD2-anchored dynein stretches the MTOCs into fragmented ribbons along the nuclear envelope. Third, KIF11 further fragments the MTOCs following nuclear envelope breakdown so that they can be evenly distributed towards the two spindle poles. Failure to fragment MTOCs leads to defects in spindle assembly, which delay chromosome individualization and congression, putting the oocyte at risk of aneuploidy." @default.
- W805741100 created "2016-06-24" @default.
- W805741100 creator A5029489083 @default.
- W805741100 creator A5075832070 @default.
- W805741100 date "2015-07-06" @default.
- W805741100 modified "2023-10-01" @default.
- W805741100 title "A three-step MTOC fragmentation mechanism facilitates bipolar spindle assembly in mouse oocytes" @default.
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- W805741100 doi "https://doi.org/10.1038/ncomms8217" @default.
- W805741100 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4501430" @default.
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