FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W80575831> ?p ?o ?g. }

• W80575831 endingPage "200" @default.
• W80575831 startingPage "181" @default.
• W80575831 abstract "Tumor dormancy occurs when cancer cells are present but the tumor does not grow. Following treatment, patients may enter complete remission in which persistent cells represent the minimal residual disease (MRD). Experimental models and clinical data suggest that the absolute quantity of this MRD is extremely low. Very few cancer cells can persist for years or decades under these hostile conditions that include continuous exposure to maintenance treatment, autologous anti-tumor immune response, and a nonpermissive microenvironment. Dormant tumor cells may survive despite these destruction factors if they adapt and develop strategies to escape from cell death. Escape may result in a state of equilibrium between MRD and the patient. Equilibrium between the immune response and tumor cells can result in long-term tumor dormancy; however, after variable lengths of time, tumor dormancy ends, and the disease progresses. Experimental models have shown that dormant tumor cells may over-express B7-H1 and B7.1 and inhibit cytotoxic T-cellmediated lysis. This resistance could be therapeutically targeted using drugs like MEK inhibitors that modulate pathways involved in B7-H1 expression. Dormant tumor cells may also develop nonspecific resistance mechanisms to cell death, such as deregulation of JAK/STAT and mTORC2/AKT pathways or autocrine and paracrine production of cytokines. This deregulation leads to cross-resistance between the immune response and cytotoxic drugs, indicating that the long-term selection that occurs in vivo during tumor dormancy may ultimately result in resistant relapse. Long-term selection of cancer cells in vitro using tyrosine kinase inhibitors selects cells that harbor the same resistance mechanisms as dormant tumor cells. Elucidating the mechanisms underlying the equilibrium that allows for the persistence of dormant tumor cells presents a novel strategy for targeted drug treatment in the context of maintenance therapy." @default.
• W80575831 created "2016-06-24" @default.
• W80575831 creator A5067465993 @default.
• W80575831 date "2012-08-30" @default.
• W80575831 modified "2023-10-03" @default.
• W80575831 title "Tumor Dormancy: Long-Term Survival in a Hostile Environment" @default.
• W80575831 cites W1520440593 @default.
• W80575831 cites W1733656319 @default.
• W80575831 cites W1965518221 @default.
• W80575831 cites W1967358345 @default.
• W80575831 cites W1969930112 @default.
• W80575831 cites W1971318332 @default.
• W80575831 cites W1971641493 @default.
• W80575831 cites W1972715557 @default.
• W80575831 cites W1976810575 @default.
• W80575831 cites W1998142996 @default.
• W80575831 cites W1998618250 @default.
• W80575831 cites W2001593231 @default.
• W80575831 cites W2004124992 @default.
• W80575831 cites W2004411316 @default.
• W80575831 cites W2012487145 @default.
• W80575831 cites W2014590681 @default.
• W80575831 cites W2015301884 @default.
• W80575831 cites W2016983859 @default.
• W80575831 cites W2020131167 @default.
• W80575831 cites W2021588881 @default.
• W80575831 cites W2022179692 @default.
• W80575831 cites W2023560061 @default.
• W80575831 cites W2028085190 @default.
• W80575831 cites W2028376975 @default.
• W80575831 cites W2029299243 @default.
• W80575831 cites W2033710771 @default.
• W80575831 cites W2044224425 @default.
• W80575831 cites W2045854741 @default.
• W80575831 cites W2052661901 @default.
• W80575831 cites W2056680264 @default.
• W80575831 cites W2059018375 @default.
• W80575831 cites W2060383229 @default.
• W80575831 cites W2062166095 @default.
• W80575831 cites W2062889582 @default.
• W80575831 cites W2063264144 @default.
• W80575831 cites W2063858545 @default.
• W80575831 cites W2064837930 @default.
• W80575831 cites W2068921729 @default.
• W80575831 cites W2076217021 @default.
• W80575831 cites W2086437355 @default.
• W80575831 cites W2093144236 @default.
• W80575831 cites W2094912768 @default.
• W80575831 cites W2096151993 @default.
• W80575831 cites W2097519948 @default.
• W80575831 cites W2097862336 @default.
• W80575831 cites W2097969181 @default.
• W80575831 cites W2099906751 @default.
• W80575831 cites W2101648653 @default.
• W80575831 cites W2103478462 @default.
• W80575831 cites W2120915581 @default.
• W80575831 cites W2122224021 @default.
• W80575831 cites W2123363005 @default.
• W80575831 cites W2128798967 @default.
• W80575831 cites W2129228597 @default.
• W80575831 cites W2136379419 @default.
• W80575831 cites W2138817111 @default.
• W80575831 cites W2150883611 @default.
• W80575831 cites W2153745983 @default.
• W80575831 cites W2154697747 @default.
• W80575831 cites W2155464214 @default.
• W80575831 cites W2156106286 @default.
• W80575831 cites W2160807638 @default.
• W80575831 cites W2163242247 @default.
• W80575831 cites W2168219416 @default.
• W80575831 cites W2171298396 @default.
• W80575831 cites W2302140131 @default.
• W80575831 cites W2312296163 @default.
• W80575831 cites W2326604218 @default.
• W80575831 cites W2334454364 @default.
• W80575831 cites W2336302298 @default.
• W80575831 cites W2405444975 @default.
• W80575831 cites W2439183249 @default.
• W80575831 cites W2463158611 @default.
• W80575831 cites W2806760348 @default.
• W80575831 cites W4313335092 @default.
• W80575831 doi "https://doi.org/10.1007/978-1-4614-1445-2_9" @default.
• W80575831 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23143980" @default.
• W80575831 hasPublicationYear "2012" @default.
• W80575831 type Work @default.
• W80575831 sameAs 80575831 @default.
• W80575831 citedByCount "12" @default.
• W80575831 countsByYear W805758312013 @default.
• W80575831 countsByYear W805758312014 @default.
• W80575831 countsByYear W805758312015 @default.
• W80575831 countsByYear W805758312016 @default.
• W80575831 countsByYear W805758312017 @default.
• W80575831 countsByYear W805758312020 @default.
• W80575831 countsByYear W805758312022 @default.
• W80575831 countsByYear W805758312023 @default.
• W80575831 crossrefType "book-chapter" @default.
• W80575831 hasAuthorship W80575831A5067465993 @default.
• W80575831 hasConcept C100701293 @default.

• next