FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W80588478> ?p ?o ?g. }

• W80588478 abstract "A decrease in the rate of active Ca2+ uptake into the SR is a central feature in human and animal heart failure. Several studies indicated that the mRNA- as well as the protein levels of the sarcoplasmic reticulum (SR) Ca2+ ATPase (encoded by SERCA2 gene) are reduced in hypertrophied and failing myocardium. On the other hand, investigations on phospholamban (PLB) knock-out and phospholamban transgenic mice have proven that the expression ratio of PLB- to SERCA2a- protein is an important determinant of SR function. More recently, it was shown via complementation of the genetically based mouse model of dilated cardiomyopathy (muscle-specific LIM-domain cytoskeletal protein (MLP) knock-outs) that development of heart failure is dependent on a Ca2+ cycling defect in the cardiac SR. Remarkably, double MLP/PLB knockout mice display a rescue of the entire spectrum of MLP deficient heart failure phenotype at the structural, functional and molecular level. The state of knowledge on the molecular aspects and physiological functions of SERCA2a by PLB is briefly reviewed. Alltogether, these observations on PLB function have led us to explore novel strategies of interference by genetic manipulation of PLB-SERCA2a interaction to provide a basis for future development of gene therapy for improving function of the failing myocardium. With this aim we explored the antisense RNA strategy directed against de novo synthesis of PLB. Because the option of in vitro and in vitro gene transfer into the heart by replication-deficient adenovirus had already been proven, recombinant adenoviral vectors expressing PLB-antisense were prepared under control of cytomegalovirus (CMV) as well as an atrial natriuretic factor (ANF) promoter. Although at present the principle has still not been tested in vivo, our in vitro results obtained with isolated beating rat cardiomyocytes strongly suggest that vector-mediated PLB-antisense-RNA expression may become a feasible approach to improve function of the failing heart. Furthermore, the endothelin-1 inducible ANF promoter offers the perspective for “induction-by disease” gene therapy by selective expression of therapeutic genes in the hypertrophied and failing myocytes." @default.
• W80588478 created "2016-06-24" @default.
• W80588478 creator A5037797176 @default.
• W80588478 creator A5046614524 @default.
• W80588478 creator A5049477911 @default.
• W80588478 creator A5058971565 @default.
• W80588478 creator A5068871940 @default.
• W80588478 creator A5079920375 @default.
• W80588478 creator A5080094302 @default.
• W80588478 date "2003-01-01" @default.
• W80588478 modified "2023-10-16" @default.
• W80588478 title "Sarcoplasmic Reticulum Proteins as Potential Targets for Gene Therapy of Heart Failure" @default.
• W80588478 cites W1495886405 @default.
• W80588478 cites W1986156860 @default.
• W80588478 cites W1989282030 @default.
• W80588478 cites W1999242870 @default.
• W80588478 cites W2004786427 @default.
• W80588478 cites W2010576268 @default.
• W80588478 cites W2010833762 @default.
• W80588478 cites W2011762615 @default.
• W80588478 cites W2018228900 @default.
• W80588478 cites W2021212178 @default.
• W80588478 cites W2023591835 @default.
• W80588478 cites W2027204345 @default.
• W80588478 cites W2030549364 @default.
• W80588478 cites W2033468971 @default.
• W80588478 cites W2035834158 @default.
• W80588478 cites W2037961063 @default.
• W80588478 cites W2041088809 @default.
• W80588478 cites W2048867275 @default.
• W80588478 cites W2050599536 @default.
• W80588478 cites W2053917755 @default.
• W80588478 cites W2061010117 @default.
• W80588478 cites W2061245367 @default.
• W80588478 cites W2064062531 @default.
• W80588478 cites W2067021372 @default.
• W80588478 cites W2068671266 @default.
• W80588478 cites W2069813140 @default.
• W80588478 cites W2071763225 @default.
• W80588478 cites W2086501606 @default.
• W80588478 cites W2094065595 @default.
• W80588478 cites W2108518355 @default.
• W80588478 cites W2124114189 @default.
• W80588478 cites W2145086834 @default.
• W80588478 cites W2149733176 @default.
• W80588478 cites W2151534641 @default.
• W80588478 cites W2157168028 @default.
• W80588478 cites W2164900052 @default.
• W80588478 cites W2317845988 @default.
• W80588478 cites W2323800150 @default.
• W80588478 cites W58055601 @default.
• W80588478 cites W74331461 @default.
• W80588478 doi "https://doi.org/10.1007/978-1-4419-9262-8_6" @default.
• W80588478 hasPublicationYear "2003" @default.
• W80588478 type Work @default.
• W80588478 sameAs 80588478 @default.
• W80588478 citedByCount "0" @default.
• W80588478 crossrefType "book-chapter" @default.
• W80588478 hasAuthorship W80588478A5037797176 @default.
• W80588478 hasAuthorship W80588478A5046614524 @default.
• W80588478 hasAuthorship W80588478A5049477911 @default.
• W80588478 hasAuthorship W80588478A5058971565 @default.
• W80588478 hasAuthorship W80588478A5068871940 @default.
• W80588478 hasAuthorship W80588478A5079920375 @default.
• W80588478 hasAuthorship W80588478A5080094302 @default.
• W80588478 hasConcept C102230213 @default.
• W80588478 hasConcept C104317684 @default.
• W80588478 hasConcept C111599444 @default.
• W80588478 hasConcept C126322002 @default.
• W80588478 hasConcept C153911025 @default.
• W80588478 hasConcept C158617107 @default.
• W80588478 hasConcept C17137333 @default.
• W80588478 hasConcept C185592680 @default.
• W80588478 hasConcept C2778198053 @default.
• W80588478 hasConcept C54355233 @default.
• W80588478 hasConcept C71924100 @default.
• W80588478 hasConcept C86803240 @default.
• W80588478 hasConcept C95444343 @default.
• W80588478 hasConceptScore W80588478C102230213 @default.
• W80588478 hasConceptScore W80588478C104317684 @default.
• W80588478 hasConceptScore W80588478C111599444 @default.
• W80588478 hasConceptScore W80588478C126322002 @default.
• W80588478 hasConceptScore W80588478C153911025 @default.
• W80588478 hasConceptScore W80588478C158617107 @default.
• W80588478 hasConceptScore W80588478C17137333 @default.
• W80588478 hasConceptScore W80588478C185592680 @default.
• W80588478 hasConceptScore W80588478C2778198053 @default.
• W80588478 hasConceptScore W80588478C54355233 @default.
• W80588478 hasConceptScore W80588478C71924100 @default.
• W80588478 hasConceptScore W80588478C86803240 @default.
• W80588478 hasConceptScore W80588478C95444343 @default.
• W80588478 hasLocation W805884781 @default.
• W80588478 hasOpenAccess W80588478 @default.
• W80588478 hasPrimaryLocation W805884781 @default.
• W80588478 hasRelatedWork W1992753622 @default.
• W80588478 hasRelatedWork W2001553526 @default.
• W80588478 hasRelatedWork W2039995053 @default.
• W80588478 hasRelatedWork W2125804349 @default.
• W80588478 hasRelatedWork W2322900513 @default.
• W80588478 hasRelatedWork W2381296302 @default.

• next