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- W80601831 abstract "This chapter describes the impaired natural killer (NK) cell function in multiple sclerosis (MS) and association with the HLA system. In a study described in the chapter, 133 patients were studied, 52 male and 81 female. At the time of examination, 33 had exacerbation, 57 were in remission, and 43 were in a slowly progressive state. Blood samples were taken within the first month of remission. No immunosuppressive drugs were administered, except for three patients who were treated by corticosteroids. In cytotoxicity assay method, Ficoll–Uromiro separated and carbonyl-iron treated peripheral blood mononuclear cells were mixed with 51-chromium labeled target cells K-562 in double stepwise dilution from 50:1 to 3:1 effector to target cell ratios in four parallels. Supernatants of the plate cultures were taken after 4 h of incubation and the level of radioactivity was determined. Based on the dose-response line, the cytotoxicity value for 20:1 effector to target cell ratio was computed and used as a stabilized comparative value. In Hungary, 133 MS patients were HLA-typed and compared with a healthy population. The comparison revealed significant association, with B7, 32.3% versus 15.1%; and DR2 antigen, 42.7% versus 19.1%. Other deviations A28 and B12 did not reach the level of significance." @default.
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- W80601831 date "1982-01-01" @default.
- W80601831 modified "2023-09-23" @default.
- W80601831 title "IMPAIRED NATURAL KILLER CELL FUNCTION IN MULTIPLE SCLEROSIS AND ASSOCIATION WITH THE HLA SYSTEM" @default.
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- W80601831 doi "https://doi.org/10.1016/b978-0-12-341360-4.50181-5" @default.
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