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• W806055413 abstract "The CAS (Crk-associated substrate) adaptor protein family consists of four members: CASS1/BCAR1/p130Cas, CASS2/NEDD9/HEF1/Cas-L, CASS3/EFS/Sin and CASS4/HEPL. While CAS proteins lack enzymatic activity, they contain specific recognition and binding sites for assembly of larger signaling complexes that are essential for cell proliferation, survival, migration, and other processes. All family members are intermediates in integrin-dependent signaling pathways mediated at focal adhesions, and associate with FAK and SRC family kinases to activate downstream effectors regulating the actin cytoskeleton. Most studies of CAS proteins to date have been focused on the first two members, BCAR1 and NEDD9, with altered expression of these proteins now appreciated as influencing disease development and prognosis for cancer and other serious pathological conditions. For these family members, additional mechanisms of action have been defined in receptor tyrosine kinase (RTK) signaling, estrogen receptor signaling or cell cycle progression, involving discrete partner proteins such as SHC, NSP proteins, or AURKA. By contrast, EFS and CASS4 have been less studied, although structure–function analyses indicate they conserve many elements with the better-known family members. Intriguingly, a number of recent studies have implicated these proteins in immune system function, and the pathogenesis of developmental disorders, autoimmune disorders including Crohn's disease, Alzheimer's disease, cancer and other diseases. In this review, we summarize the current understanding of EFS and CASS4 protein function in the context of the larger CAS family group." @default.
• W806055413 created "2016-06-24" @default.
• W806055413 creator A5003483571 @default.
• W806055413 creator A5004302234 @default.
• W806055413 creator A5079033969 @default.
• W806055413 date "2015-10-01" @default.
• W806055413 modified "2023-10-16" @default.
• W806055413 title "Embryonal Fyn-associated substrate (EFS) and CASS4: The lesser-known CAS protein family members" @default.
• W806055413 cites W1566547188 @default.
• W806055413 cites W1571215888 @default.
• W806055413 cites W1577110585 @default.
• W806055413 cites W1605981966 @default.
• W806055413 cites W1668085705 @default.
• W806055413 cites W1672729420 @default.
• W806055413 cites W1900495018 @default.
• W806055413 cites W1923713269 @default.
• W806055413 cites W1964246500 @default.
• W806055413 cites W1966293552 @default.
• W806055413 cites W1972533209 @default.
• W806055413 cites W1973741121 @default.
• W806055413 cites W1975132186 @default.
• W806055413 cites W1975652063 @default.
• W806055413 cites W1976214697 @default.
• W806055413 cites W1980209238 @default.
• W806055413 cites W1990609613 @default.
• W806055413 cites W1999353750 @default.
• W806055413 cites W1999794509 @default.
• W806055413 cites W2001386699 @default.
• W806055413 cites W2006705432 @default.
• W806055413 cites W2017396700 @default.
• W806055413 cites W2019706392 @default.
• W806055413 cites W2024653595 @default.
• W806055413 cites W2026182009 @default.
• W806055413 cites W2026306905 @default.
• W806055413 cites W2028105686 @default.
• W806055413 cites W2028752761 @default.
• W806055413 cites W2032588409 @default.
• W806055413 cites W2032770293 @default.
• W806055413 cites W2033174055 @default.
• W806055413 cites W2033799985 @default.
• W806055413 cites W2034246730 @default.
• W806055413 cites W2034716886 @default.
• W806055413 cites W2036313024 @default.
• W806055413 cites W2036801330 @default.
• W806055413 cites W2040703771 @default.
• W806055413 cites W2043058822 @default.
• W806055413 cites W2043595517 @default.
• W806055413 cites W2044346799 @default.
• W806055413 cites W2044822003 @default.
• W806055413 cites W2044871902 @default.
• W806055413 cites W2054192585 @default.
• W806055413 cites W2059797892 @default.
• W806055413 cites W2063259786 @default.
• W806055413 cites W2063940468 @default.
• W806055413 cites W2067362444 @default.
• W806055413 cites W2072063447 @default.
• W806055413 cites W2076401374 @default.
• W806055413 cites W2083763767 @default.
• W806055413 cites W2088446425 @default.
• W806055413 cites W2092398847 @default.
• W806055413 cites W2093043664 @default.
• W806055413 cites W2093744073 @default.
• W806055413 cites W2094757420 @default.
• W806055413 cites W2096896583 @default.
• W806055413 cites W2099290597 @default.
• W806055413 cites W2099481097 @default.
• W806055413 cites W2099618574 @default.
• W806055413 cites W2100495829 @default.
• W806055413 cites W2105752911 @default.
• W806055413 cites W2106779017 @default.
• W806055413 cites W2112367826 @default.
• W806055413 cites W2112707395 @default.
• W806055413 cites W2115779804 @default.
• W806055413 cites W2121513532 @default.
• W806055413 cites W2122190723 @default.
• W806055413 cites W2126859572 @default.
• W806055413 cites W2127571585 @default.
• W806055413 cites W2127792712 @default.
• W806055413 cites W2131328125 @default.
• W806055413 cites W2131728143 @default.
• W806055413 cites W2131922349 @default.
• W806055413 cites W2135178995 @default.
• W806055413 cites W2140751337 @default.
• W806055413 cites W2142042013 @default.
• W806055413 cites W2144195261 @default.
• W806055413 cites W2144687681 @default.
• W806055413 cites W2147177984 @default.
• W806055413 cites W2150087878 @default.
• W806055413 cites W2151466864 @default.
• W806055413 cites W2151903377 @default.
• W806055413 cites W2153390050 @default.
• W806055413 cites W2159018836 @default.
• W806055413 cites W2164682544 @default.
• W806055413 cites W2165872127 @default.
• W806055413 cites W2167682559 @default.
• W806055413 cites W2169932670 @default.
• W806055413 cites W2170841351 @default.
• W806055413 cites W2171698295 @default.

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