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- W806347796 abstract "Protein destruction may seem like a strange wayfor a cell to control its growth. The entire processby which cells multiply is based on synthesistheduplication of almost every molecule in thecell. If protein synthesis is one of the foundationsof growth, then why are so many proteins destroyedas one cell becomes two?The answer to this question is control. Theprocess of cell duplication is, of course, morecomplicated than simply replicating the cellularcontents and dividing. Survival of all eukaryoticcells depends on their ability to regulate how andwhen they grow. To persist, cells must multiplyonly in response to specific signals, they musthave mechanisms to detect errors in the duplicationprocess, and they must establish a definedsequence for the events of duplication, so thatDNA replication, for example, always precedescell division. In addition to synthesis, therefore,an important part of growth is maintaining tightcontrol over all of the proteins needed to make anew cell. Protein destruction-proteolysisplaysa pivotal role in controlling the activity ofthese proteins." @default.
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- W806347796 title "How Cells Use Proteolysis to Control Their Growth" @default.
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- W806347796 doi "https://doi.org/10.1007/bf03401990" @default.
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