Matches in SemOpenAlex for { <https://semopenalex.org/work/W80641656> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W80641656 endingPage "366" @default.
- W80641656 startingPage "363" @default.
- W80641656 abstract "Our previous studies have demonstrated that argatroban, a specific thrombin inhibitor, reduces brain edema and neurological deficits in rat glioma models. The present study investigated whether or not thrombin enhances glioma growth in vivo and in vitro.There were two parts in this study. In the first part, rat C6 glioma cells were treated with or without thrombin. These cells were then injected into the right caudate of adult male Fischer 344 rats. Rats underwent behavioral testing prior to sacrifice 12 days later for tumor mass measurement. In the second part, C6 cells were incubated in serum-free medium for 24 hours and then treated with thrombin with or without argatroban, a thrombin inhibitor. DNA synthesis was examined using a 5-bromo-2'-deoxyuridine (BrdU) ELISA kit. Cell proliferation was determined using a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide (MTT) assay.Treatment of C6 cells with thrombin prior to intracerebral implantation resulted in a larger tumor mass and worse neurological deficits at dayl2. In vitro, thrombin increased DNA synthesis in C6 glioma cells, and this effect was blocked by argatroban. MTT assay showed that thrombin significantly increased glioma cell proliferation in vitro.In summary, thrombin enhances C6 glioma growth in vivo and cell proliferation in vitro suggesting that thrombin may be a target of glioma therapy." @default.
- W80641656 created "2016-06-24" @default.
- W80641656 creator A5027926846 @default.
- W80641656 creator A5030364722 @default.
- W80641656 creator A5030665713 @default.
- W80641656 creator A5034051366 @default.
- W80641656 creator A5046564292 @default.
- W80641656 creator A5065005554 @default.
- W80641656 creator A5083834388 @default.
- W80641656 date "2008-01-01" @default.
- W80641656 modified "2023-09-27" @default.
- W80641656 title "Thrombin enhances glioma growth" @default.
- W80641656 cites W104200126 @default.
- W80641656 cites W1594129908 @default.
- W80641656 cites W1971381858 @default.
- W80641656 cites W1972537662 @default.
- W80641656 cites W2050221835 @default.
- W80641656 cites W2050232551 @default.
- W80641656 cites W2050940330 @default.
- W80641656 cites W2068588301 @default.
- W80641656 cites W2071765062 @default.
- W80641656 cites W2100167607 @default.
- W80641656 cites W2126460111 @default.
- W80641656 cites W2165139012 @default.
- W80641656 cites W2188302527 @default.
- W80641656 cites W2279690993 @default.
- W80641656 cites W3113181238 @default.
- W80641656 doi "https://doi.org/10.1007/978-3-211-85578-2_69" @default.
- W80641656 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19388346" @default.
- W80641656 hasPublicationYear "2008" @default.
- W80641656 type Work @default.
- W80641656 sameAs 80641656 @default.
- W80641656 citedByCount "4" @default.
- W80641656 countsByYear W806416562013 @default.
- W80641656 countsByYear W806416562016 @default.
- W80641656 countsByYear W806416562018 @default.
- W80641656 countsByYear W806416562022 @default.
- W80641656 crossrefType "book-chapter" @default.
- W80641656 hasAuthorship W80641656A5027926846 @default.
- W80641656 hasAuthorship W80641656A5030364722 @default.
- W80641656 hasAuthorship W80641656A5030665713 @default.
- W80641656 hasAuthorship W80641656A5034051366 @default.
- W80641656 hasAuthorship W80641656A5046564292 @default.
- W80641656 hasAuthorship W80641656A5065005554 @default.
- W80641656 hasAuthorship W80641656A5083834388 @default.
- W80641656 hasConcept C150903083 @default.
- W80641656 hasConcept C185592680 @default.
- W80641656 hasConcept C202751555 @default.
- W80641656 hasConcept C203014093 @default.
- W80641656 hasConcept C207001950 @default.
- W80641656 hasConcept C2777292125 @default.
- W80641656 hasConcept C2778227246 @default.
- W80641656 hasConcept C2779612170 @default.
- W80641656 hasConcept C2780783641 @default.
- W80641656 hasConcept C502942594 @default.
- W80641656 hasConcept C55493867 @default.
- W80641656 hasConcept C57002609 @default.
- W80641656 hasConcept C71924100 @default.
- W80641656 hasConcept C86803240 @default.
- W80641656 hasConcept C89560881 @default.
- W80641656 hasConcept C98274493 @default.
- W80641656 hasConceptScore W80641656C150903083 @default.
- W80641656 hasConceptScore W80641656C185592680 @default.
- W80641656 hasConceptScore W80641656C202751555 @default.
- W80641656 hasConceptScore W80641656C203014093 @default.
- W80641656 hasConceptScore W80641656C207001950 @default.
- W80641656 hasConceptScore W80641656C2777292125 @default.
- W80641656 hasConceptScore W80641656C2778227246 @default.
- W80641656 hasConceptScore W80641656C2779612170 @default.
- W80641656 hasConceptScore W80641656C2780783641 @default.
- W80641656 hasConceptScore W80641656C502942594 @default.
- W80641656 hasConceptScore W80641656C55493867 @default.
- W80641656 hasConceptScore W80641656C57002609 @default.
- W80641656 hasConceptScore W80641656C71924100 @default.
- W80641656 hasConceptScore W80641656C86803240 @default.
- W80641656 hasConceptScore W80641656C89560881 @default.
- W80641656 hasConceptScore W80641656C98274493 @default.
- W80641656 hasLocation W806416561 @default.
- W80641656 hasLocation W806416562 @default.
- W80641656 hasOpenAccess W80641656 @default.
- W80641656 hasPrimaryLocation W806416561 @default.
- W80641656 hasRelatedWork W1970676078 @default.
- W80641656 hasRelatedWork W1986000434 @default.
- W80641656 hasRelatedWork W2055893076 @default.
- W80641656 hasRelatedWork W2084893782 @default.
- W80641656 hasRelatedWork W2126460111 @default.
- W80641656 hasRelatedWork W233116462 @default.
- W80641656 hasRelatedWork W2376022936 @default.
- W80641656 hasRelatedWork W2377642878 @default.
- W80641656 hasRelatedWork W3145930343 @default.
- W80641656 hasRelatedWork W4231382193 @default.
- W80641656 isParatext "false" @default.
- W80641656 isRetracted "false" @default.
- W80641656 magId "80641656" @default.
- W80641656 workType "book-chapter" @default.