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- W80687245 abstract "The passage of substances across the blood-brain barrier (BBB) is regulated in cerebral capillaries, which possess certain distinct different morphological and enzymatic properties compared with the capillaries of other organs. The endothelial cells of brain capillaries are sealed together by continuous tight junctions and have little transcellular vesicular transport (1). In addition, a number of proteins are specifically expressed by brain endothelial cells that may be required for metabolic protection or transport activities at the BBB interface. Because of these characteristics, the BBB is a regulatory interface that may limit or impair the delivery of drugs to the central nervous system as compared to other tissues." @default.
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- W80687245 date "1993-01-01" @default.
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- W80687245 title "Drug Transfer Across the Blood-Brain Barrier: Comparison of in Vitro and in Vivo Models" @default.
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- W80687245 doi "https://doi.org/10.1007/978-1-4615-2920-0_18" @default.
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