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- W80692717 abstract "The interferon-inducible, double-stranded (ds)RNA-activated protein kinase PKR is clearly an important mediator of interferon action and has also been implicated in the induction of apoptosis (Lee and Esteban 1994; Kibler et al. 1997) and in the inhibition of cellular protein synthesis in virus-infected cells. Much of the compelling evidence for the role of PKR in virus replication has come from the study of viruses such as reovirus that encode inhibitors of PKR. This review will discuss the genetic and biochemical data suggesting that reovirus σ3 protein, acting as a dsRNA-binding protein, functions as an inhibitor of PKR." @default.
- W80692717 created "2016-06-24" @default.
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- W80692717 date "1998-01-01" @default.
- W80692717 modified "2023-10-03" @default.
- W80692717 title "Reovirus σ3 Protein: dsRNA Binding and Inhibition of RNA-Activated Protein Kinase" @default.
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- W80692717 doi "https://doi.org/10.1007/978-3-642-72092-5_9" @default.
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