Matches in SemOpenAlex for { <https://semopenalex.org/work/W8069308> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W8069308 abstract "Approximately 15-20% of human cancers are associated with viral agents (Parkin, 2006). The human tumour virus Kaposi’s sarcoma associated herpesvirus (KSHV) is one such virus. It is the aetiological agent of the AIDS-defining malignancy Kaposi’s sarcoma (KS) and primary effusion lymphoma (PEL), and is linked to the development of multi-centric Castleman’s disease (MCD). As a herpesvirus, KSHV resides in a latent state within infected host cells, evading various innate and adaptive immune mechanisms. The widely expressed and highly conserved toll-like receptor (TLR) family plays a major role in binding of pathogen-associated molecular patterns (PAMPs), thus identifying pathogens and leading to the stimulation of relevant host immune responses. Members of the Herpesviridae family are known to act upon, interact with and/or be detected by certain TLRs. Based on this precedence, we have investigated the interaction of KSHV on human TLRs in the human epithelial kidney cell line, 293. We evaluated the initial effect of ectopic TLR expression on KSHV infection level and the effect of KSHV infection on ectopic TLR transcript levels. Using flow cytometry, we found that KSHV infection is sensitive to the expression of TLRs 2, 3, 4 and 5, presumably via KSHV PAMP recognition, and is not sensitive to the ectopic expression of TLRs 1, 6, 7, 8 and 9. Semi-quantitative PCR revealed that TLR 7 mRNA levels are decreased by KSHV infection. We suggest that this result indicates that KSHV utilises some mechanism to decrease mRNA levels in order to evade potential antiviral responses triggered by the receptor." @default.
- W8069308 created "2016-06-24" @default.
- W8069308 creator A5039157217 @default.
- W8069308 date "2011-12-01" @default.
- W8069308 modified "2023-09-26" @default.
- W8069308 title "The interactions of Kaposi's sarcoma-associated herpesvirus with human toll-like receptors and human papillomavirus and pdz-domain containing proteins" @default.
- W8069308 hasPublicationYear "2011" @default.
- W8069308 type Work @default.
- W8069308 sameAs 8069308 @default.
- W8069308 citedByCount "0" @default.
- W8069308 crossrefType "dissertation" @default.
- W8069308 hasAuthorship W8069308A5039157217 @default.
- W8069308 hasConcept C136449434 @default.
- W8069308 hasConcept C159047783 @default.
- W8069308 hasConcept C203014093 @default.
- W8069308 hasConcept C2522874641 @default.
- W8069308 hasConcept C2776409557 @default.
- W8069308 hasConcept C2779236070 @default.
- W8069308 hasConcept C2779594685 @default.
- W8069308 hasConcept C2780727368 @default.
- W8069308 hasConcept C2780797929 @default.
- W8069308 hasConcept C3018958071 @default.
- W8069308 hasConcept C54355233 @default.
- W8069308 hasConcept C81885089 @default.
- W8069308 hasConcept C86803240 @default.
- W8069308 hasConcept C8891405 @default.
- W8069308 hasConcept C97037327 @default.
- W8069308 hasConceptScore W8069308C136449434 @default.
- W8069308 hasConceptScore W8069308C159047783 @default.
- W8069308 hasConceptScore W8069308C203014093 @default.
- W8069308 hasConceptScore W8069308C2522874641 @default.
- W8069308 hasConceptScore W8069308C2776409557 @default.
- W8069308 hasConceptScore W8069308C2779236070 @default.
- W8069308 hasConceptScore W8069308C2779594685 @default.
- W8069308 hasConceptScore W8069308C2780727368 @default.
- W8069308 hasConceptScore W8069308C2780797929 @default.
- W8069308 hasConceptScore W8069308C3018958071 @default.
- W8069308 hasConceptScore W8069308C54355233 @default.
- W8069308 hasConceptScore W8069308C81885089 @default.
- W8069308 hasConceptScore W8069308C86803240 @default.
- W8069308 hasConceptScore W8069308C8891405 @default.
- W8069308 hasConceptScore W8069308C97037327 @default.
- W8069308 hasLocation W80693081 @default.
- W8069308 hasOpenAccess W8069308 @default.
- W8069308 hasPrimaryLocation W80693081 @default.
- W8069308 hasRelatedWork W1565871504 @default.
- W8069308 hasRelatedWork W2010800481 @default.
- W8069308 hasRelatedWork W2030912631 @default.
- W8069308 hasRelatedWork W2066768017 @default.
- W8069308 hasRelatedWork W2076107968 @default.
- W8069308 hasRelatedWork W2081237630 @default.
- W8069308 hasRelatedWork W2086196885 @default.
- W8069308 hasRelatedWork W2091719796 @default.
- W8069308 hasRelatedWork W2105638799 @default.
- W8069308 hasRelatedWork W2113094330 @default.
- W8069308 hasRelatedWork W2123467929 @default.
- W8069308 hasRelatedWork W2129505790 @default.
- W8069308 hasRelatedWork W2143090686 @default.
- W8069308 hasRelatedWork W2146222237 @default.
- W8069308 hasRelatedWork W2480879944 @default.
- W8069308 hasRelatedWork W2494854563 @default.
- W8069308 hasRelatedWork W2608813681 @default.
- W8069308 hasRelatedWork W2922474059 @default.
- W8069308 hasRelatedWork W3093251266 @default.
- W8069308 hasRelatedWork W3123216777 @default.
- W8069308 isParatext "false" @default.
- W8069308 isRetracted "false" @default.
- W8069308 magId "8069308" @default.
- W8069308 workType "dissertation" @default.