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- W80699635 abstract "textabstractThe human intestine contains about 1014 micro-organisms that criticallycontribute totissue homeostasis, host metabolism and other benefi cial processes.Despite a continuousmicrobial exposure within in the intestine, the mucosal immune system isable tomaintain a state of tolerance to the microbiota. An aberrant immuneresponse of theintestinal immune system results in a defective tolerance in theintestine, which leads toa breakdown of intestinal homeostasis. This in turn, can lead to chronicintestinal infl ammationor inflammatory bowel disease (IBD).From an immunological perspective, exaggerated responses by mucosal T andB cells(the adaptive immune system) have traditionally been regarded as the keycontributorsto the pathogenesis of IBD. However, discoveries of innate defects thatare associatedwith IBD have refocused the attention to this arm of the immune system.In this thesis we try to answer some of the open questions concerning thepathogenesisof IBD and defects in the innate immune system." @default.
- W80699635 created "2016-06-24" @default.
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- W80699635 date "2010-09-15" @default.
- W80699635 modified "2023-09-27" @default.
- W80699635 title "The Role Of The Innate Immune System In Infl ammatory Bowel Disease: We have met the enemy and he is us" @default.
- W80699635 hasPublicationYear "2010" @default.
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