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- W807065188 abstract "Objectives: The root of Rhodiola sachalinensis A. bar (RS), which has been used to strengthen qi (補氣), reduce heat of lung (淸肺), nourish heart (養心), stop bleeding (止血), reduce edema (消腫) for the treatment of fatigue, amnesia, bleeding and edema. It's flavour and channel tropism is sweet (甘), acting on the lung (肺). The purpose of the study we report here was to determine the neuroprotective effect of the roots of RS on transient focal cerebral ischemia in SD rats. Methods: The root of RS was lyophilized after extraction with methanol. We occluded middle cerebral artery for 90 minutes and reperfused for 24 hours. The brain slices were stained by 2, 3, 5-triphenyltetrazolium chloride and the infarct volume was measured by graphic analyzer. Results: The noot extracts of RS showed significant neuroprotective effects (100 mg/kg, p. Immunohistochemical data explained the protective effects of RS via attenuation of COX-2 induction in neocortex and inhibition of microglia activation in the penumbral region. Conclusions: The root of RS has neuroprotective effects on transient focal cerebral ischemia in Spargue-Dawley rats and the mechanism might be the attenuation of COX-2 induction and microglial acti vation." @default.
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- W807065188 date "2004-01-01" @default.
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- W807065188 title "Neuroprotective Effect of Rhodiola sachalinensis Extracts on Transient Focal Cerebral Ischemia in Rats" @default.
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