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- W80723002 abstract "Polycyclic heteroaromatic chromophores are popular platforms for designing G-quadruplex ligands, because of their ability to stack onto G-quartets. A number of tri-, tetra- and larger systems are discussed here, based on, for example, phenanthroline, quinoline or quindoline frameworks. Another commonly studied system is based on the porphyrin skeleton, which binds to quadruplexes in a complex manner and for which there is limited structural data. The naphthalene diimide chromophore, when tetra-substituted with alkylamino side-chains, is an effective G-quadruplex stabilizer. Crystallographic data on two complexes supports the concept that the side-chains play an important, even dominant role in the binding. By contrast the cyclic pentaoxazole natural product telomestatin has no side-chains yet is a potent quadruplex binder as well as an effective telomerase inhibitor. The structural basis for the quadruplex binding of telomestatin and synthetic mimetic compounds is analyzed." @default.
- W80723002 created "2016-06-24" @default.
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- W80723002 date "2012-01-01" @default.
- W80723002 modified "2023-09-26" @default.
- W80723002 title "Telomeric Quadruplex Ligands II" @default.
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- W80723002 doi "https://doi.org/10.1016/b978-0-12-375138-6.00005-4" @default.
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