Matches in SemOpenAlex for { <https://semopenalex.org/work/W80735305> ?p ?o ?g. }
Showing items 1 to 48 of
48
with 100 items per page.
- W80735305 endingPage "235" @default.
- W80735305 startingPage "201" @default.
- W80735305 abstract "The tropane alkaloids are found in the plant families Solanaceae, Convolvulaceae, Erythroxylaceae, Euphorbiaceae, Proteaceae and Rhizophoraceae. They resemble the pyrrolizidine alkaloids in that they are esters of relatively simple organic carboxylic acids with amino alcohols, which are all hydroxylated derivatives of tropane (8-methyl-8-azabicyclo[3.2.1]octane) or nortropane. The main chemical endeavor in the study of these alkaloids has concentrated on stereochemical aspects, biogenesis, and synthesis. In particular much synthetic work has been carried out, stimulated by the interesting pharmacological properties of the alkaloids, which have also resulted in metabolic studies of the natural compounds and their analogues. Several general synthetic methods for construction of the tropane skeleton include Robinson-Schopf synthesis, synthesis from pyrrolidines, from 2,6-cycloheptadienone, from cyclopropanones and pyrroles. It is convenient to discuss the individual tropane alkaloids in groups based on the degree of hydroxylation of the skeleton. Accordingly, these groups are: monohydroxytropanes, dihydroxytropanes, trihydroxytropane derivatives, cocaines and ecgonines. Investigation of the metabolism of tropane alkaloids [in particular atropine and (–)-scopolamine] in the mammalian body has developed rapidly with the availability of specifically labeled radioactive compounds. The mydriatic and anesthetic properties exhibited by many of the tropane bases have led to the synthesis of many synthetic analogues of the naturally occurring alkaloids." @default.
- W80735305 created "2016-06-24" @default.
- W80735305 creator A5040944504 @default.
- W80735305 creator A5089255884 @default.
- W80735305 date "1964-01-01" @default.
- W80735305 modified "2023-10-16" @default.
- W80735305 title "Five-membered Monoheterocyclic Compounds Alkaloids (continued)" @default.
- W80735305 doi "https://doi.org/10.1016/b978-044453345-6.50703-3" @default.
- W80735305 hasPublicationYear "1964" @default.
- W80735305 type Work @default.
- W80735305 sameAs 80735305 @default.
- W80735305 citedByCount "0" @default.
- W80735305 crossrefType "book-chapter" @default.
- W80735305 hasAuthorship W80735305A5040944504 @default.
- W80735305 hasAuthorship W80735305A5089255884 @default.
- W80735305 hasConcept C185592680 @default.
- W80735305 hasConcept C2776995303 @default.
- W80735305 hasConcept C2779461572 @default.
- W80735305 hasConcept C2780468241 @default.
- W80735305 hasConcept C59822182 @default.
- W80735305 hasConcept C71240020 @default.
- W80735305 hasConcept C86803240 @default.
- W80735305 hasConceptScore W80735305C185592680 @default.
- W80735305 hasConceptScore W80735305C2776995303 @default.
- W80735305 hasConceptScore W80735305C2779461572 @default.
- W80735305 hasConceptScore W80735305C2780468241 @default.
- W80735305 hasConceptScore W80735305C59822182 @default.
- W80735305 hasConceptScore W80735305C71240020 @default.
- W80735305 hasConceptScore W80735305C86803240 @default.
- W80735305 hasLocation W807353051 @default.
- W80735305 hasOpenAccess W80735305 @default.
- W80735305 hasPrimaryLocation W807353051 @default.
- W80735305 hasRelatedWork W1943585025 @default.
- W80735305 hasRelatedWork W2038832696 @default.
- W80735305 hasRelatedWork W2045596308 @default.
- W80735305 hasRelatedWork W2082729456 @default.
- W80735305 hasRelatedWork W2522395335 @default.
- W80735305 hasRelatedWork W2908055706 @default.
- W80735305 hasRelatedWork W3049345195 @default.
- W80735305 hasRelatedWork W4309715569 @default.
- W80735305 hasRelatedWork W4361733808 @default.
- W80735305 hasRelatedWork W80735305 @default.
- W80735305 isParatext "false" @default.
- W80735305 isRetracted "false" @default.
- W80735305 magId "80735305" @default.
- W80735305 workType "book-chapter" @default.