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• W80741503 endingPage "25" @default.
• W80741503 startingPage "3" @default.
• W80741503 abstract "Iron is essential for a number of biochemical functions in the body including the transport of oxygen in the blood and energy production in the mitochondria. Therefore, humans require an abundant and regular source of dietary iron to maintain normal health. This is amply demonstrated by data indicating that as many as a third of the world’s population suffer from iron deficiency, making it the most common nutrient deficiency disorder. In addition to pathologies associated with iron deficiency, excess iron is highly toxic and can lead to cell and organ damage. Interestingly, while the body levels of other dietary metals can be regulated by excretion in the feces and urine, humans do not possess the capacity to remove excess iron from the body. As a consequence, a number of proteins have evolved which tightly regulate mammalian iron homeostasis. The actions of these proteins control the rate of duodenal iron absorption, its delivery, utilization and storage by metabolically active tissues, and its recycling by reticuloendothelial macrophages." @default.
• W80741503 created "2016-06-24" @default.
• W80741503 creator A5004583942 @default.
• W80741503 creator A5075949164 @default.
• W80741503 date "2011-11-24" @default.
• W80741503 modified "2023-09-26" @default.
• W80741503 title "Proteins of Iron Homeostasis" @default.
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