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- W80776839 abstract "Since Verney's original hypothesis that the osmoreceptors are located in the vasopressin-secreting neurons themselves, numerous attempts have been made to correlate the electrical activity of these neurons with their secretory response to osmotic stimuli. This has been made possible by the ability to identify the magnocellular neurosecretory cells in vivo by their anti-dromic activation from the posterior pituitary. The responses of vasopressin (VP) cells seem to depend not only on the intensity of osmotic stimulation but also on the duration of the stimulus. Acute and short term stimulation has been done by intra-carotid injection of hypertonic solutions. In the anesthetized rat, the usual response was a brief activation of the neurons. In the unanesthetized monkey, a biphasic response to hypertonic saline injection consists of an acceleration of firing lasting 3–4 sec followed by an inhibition lasting 10–15 sec. This response appears to be confined to neurosecretory neurons. This biphasic activation of sudden onset does not appear to allow a graded response to graded changes in osmotic concentration as would be expected from a typical receptor." @default.
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- W80776839 date "1981-01-01" @default.
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- W80776839 title "OSMORECEPTORS IN THE MAMMALIAN CENTRAL NERVOUS SYSTEM" @default.
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- W80776839 doi "https://doi.org/10.1016/b978-0-08-027337-2.50047-x" @default.
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