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- W80778775 abstract "This chapter discusses the applications of principles of brain plasticity and training to restore function. Reorganization of function can occur even after the loss of hundreds of grams of brain mass, as revealed by the studies of hemispherectomized patients. It is found that while individual neurons do not appear to regenerate, there are a number of potential mechanisms of reorganization. Denervation supersensitivity results in a permanent increase in neuronal responsivity to diminished input. The receptor site may become more sensitive to a neurotransmitter or the receptors may increase in number. This may be a factor in central nervous system reorganization. Behavior compensation following brain damage can result in new combinations of behaviors. Animal studies revealed that if gangliosides are administered during the first 48 h, there seems to be an increase in TH-immunoreactive cell bodies and increased cell survival with increased functional recovery. It is stated that gangliosides may in some way positively modulate neuronal trophic influences capable of antagonizing potential neurotoxic agents." @default.
- W80778775 created "2016-06-24" @default.
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- W80778775 date "1992-01-01" @default.
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- W80778775 title "Applications of principles of brain plasticity and training to restore function" @default.
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- W80778775 doi "https://doi.org/10.1016/b978-0-7506-1172-5.50011-9" @default.
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