Matches in SemOpenAlex for { <https://semopenalex.org/work/W80797912> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W80797912 endingPage "S7" @default.
- W80797912 startingPage "S7" @default.
- W80797912 abstract "Abstract HIV-1, the cause of AIDS, preferentially replicates in IL-4 producing cells, and this coincides with a Th2 switch linked with disease progression. Others suggested differential chemokine receptor expression accounts for increased infectivity of Th2 cells. However, we confirm HIV-1 expression is increased in IL-4 producing CD4 T cells but is irrespective of viral tropism (T-tropic, M-tropic) for different chemokine receptors. Instead, we note increased HIV-1 long terminal repeat (LTR) transcription in IL-4 producing primary CD4 T cells. Using in vitro footprinting, we identified a binding site for the Th2 restricted transcription factor, c-maf (required for IL-4), located adjacent and proximal to the dual NFkB/NFAT sites in the proximal LTR. We show c-maf from activated primary CD4 T cells binds the HIV-1 LTR in vitro (EMSA) and in vivo (ChIP of virally infected cells). Interestingly, c-maf binds in conjunction with NFAT2, but not NFAT1, and with NFkB p65, but not p50. Over-expression of c-maf, NFAT2, and NFkB p65 synergistically augment HIV-1 transcription and p24/gag expression. Conversely, c-maf specific siRNA introduced into IL-4 producing primary CD4 T cells inhibits HIV-1 transcription. Thus, we identified a host factor, c-maf, present in IL-4 producing CD4 T cells that contributes to increased HIV-1 transcription in Th2 cells via binding to the LTR in cooperation with specific NFAT and NFkB family members." @default.
- W80797912 created "2016-06-24" @default.
- W80797912 creator A5010202221 @default.
- W80797912 creator A5018471006 @default.
- W80797912 date "2007-04-01" @default.
- W80797912 modified "2023-10-16" @default.
- W80797912 title "c-maf, NFAT2 and NFkB p65 specifically cooperate to augment HIV-1 transcription in IL-4 producing CD4 T cells (35.28)" @default.
- W80797912 doi "https://doi.org/10.4049/jimmunol.178.supp.35.28" @default.
- W80797912 hasPublicationYear "2007" @default.
- W80797912 type Work @default.
- W80797912 sameAs 80797912 @default.
- W80797912 citedByCount "0" @default.
- W80797912 crossrefType "journal-article" @default.
- W80797912 hasAuthorship W80797912A5010202221 @default.
- W80797912 hasAuthorship W80797912A5018471006 @default.
- W80797912 hasConcept C104317684 @default.
- W80797912 hasConcept C12823836 @default.
- W80797912 hasConcept C13373296 @default.
- W80797912 hasConcept C135576274 @default.
- W80797912 hasConcept C138885662 @default.
- W80797912 hasConcept C153911025 @default.
- W80797912 hasConcept C159047783 @default.
- W80797912 hasConcept C170493617 @default.
- W80797912 hasConcept C179926584 @default.
- W80797912 hasConcept C189938988 @default.
- W80797912 hasConcept C202751555 @default.
- W80797912 hasConcept C2522874641 @default.
- W80797912 hasConcept C35693153 @default.
- W80797912 hasConcept C41895202 @default.
- W80797912 hasConcept C54355233 @default.
- W80797912 hasConcept C86339819 @default.
- W80797912 hasConcept C86803240 @default.
- W80797912 hasConcept C95444343 @default.
- W80797912 hasConceptScore W80797912C104317684 @default.
- W80797912 hasConceptScore W80797912C12823836 @default.
- W80797912 hasConceptScore W80797912C13373296 @default.
- W80797912 hasConceptScore W80797912C135576274 @default.
- W80797912 hasConceptScore W80797912C138885662 @default.
- W80797912 hasConceptScore W80797912C153911025 @default.
- W80797912 hasConceptScore W80797912C159047783 @default.
- W80797912 hasConceptScore W80797912C170493617 @default.
- W80797912 hasConceptScore W80797912C179926584 @default.
- W80797912 hasConceptScore W80797912C189938988 @default.
- W80797912 hasConceptScore W80797912C202751555 @default.
- W80797912 hasConceptScore W80797912C2522874641 @default.
- W80797912 hasConceptScore W80797912C35693153 @default.
- W80797912 hasConceptScore W80797912C41895202 @default.
- W80797912 hasConceptScore W80797912C54355233 @default.
- W80797912 hasConceptScore W80797912C86339819 @default.
- W80797912 hasConceptScore W80797912C86803240 @default.
- W80797912 hasConceptScore W80797912C95444343 @default.
- W80797912 hasIssue "1_Supplement" @default.
- W80797912 hasLocation W807979121 @default.
- W80797912 hasOpenAccess W80797912 @default.
- W80797912 hasPrimaryLocation W807979121 @default.
- W80797912 hasRelatedWork W1896305623 @default.
- W80797912 hasRelatedWork W2011009843 @default.
- W80797912 hasRelatedWork W2025921582 @default.
- W80797912 hasRelatedWork W2052713506 @default.
- W80797912 hasRelatedWork W2088621488 @default.
- W80797912 hasRelatedWork W2125524484 @default.
- W80797912 hasRelatedWork W2404911963 @default.
- W80797912 hasRelatedWork W3165029278 @default.
- W80797912 hasRelatedWork W3182638496 @default.
- W80797912 hasRelatedWork W3198664142 @default.
- W80797912 hasVolume "178" @default.
- W80797912 isParatext "false" @default.
- W80797912 isRetracted "false" @default.
- W80797912 magId "80797912" @default.
- W80797912 workType "article" @default.