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- W80800968 abstract "This chapter provides an overview of lipoproteins, describes lipoprotein triglyceride and lipolysis, high-density lipoprotein (HDL) and plasma cholesterol metabolism, and reactions linking the metabolism of apo A1 and apo B lipoproteins. The apolipoprotein content of lipoprotein particles alters during recirculation, as changes in the lipid composition of the particles modify the affinity of apolipoproteins for their surface. Lipoprotein lipase (LPL), synthesized in adipocytes and myocytes, is transported out of the parenchymal cells, through the pericyte layer, and across the endothelium, before binding to functional sites on the vascular endothelial surface. The efflux of cholesterol from cells to plasma lipoproteins, previously considered the result of passive diffusion, is now recognized to be highly regulated by cell membrane proteins and on a par with influx as a key determinant of cellular cholesterol homeostasis. The availability of mice overexpressing or deficient in almost all known factors of plasma lipid transport has provided key insights into regulatory pathways." @default.
- W80800968 created "2016-06-24" @default.
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- W80800968 date "2002-01-01" @default.
- W80800968 modified "2023-10-05" @default.
- W80800968 title "Dynamics of lipoprotein transport in the human circulatory system" @default.
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- W80800968 doi "https://doi.org/10.1016/s0167-7306(02)36022-8" @default.
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