Matches in SemOpenAlex for { <https://semopenalex.org/work/W808198246> ?p ?o ?g. }
- W808198246 endingPage "5773" @default.
- W808198246 startingPage "5764" @default.
- W808198246 abstract "P2Y6 receptor (P2Y6-R) is involved in various physiological and pathophysiological events. With a view to set rules for the design of UDP-based reversible P2Y6-R antagonists as potential drugs, we established structure-activity relationship of UDP analogues, bearing modifications at the uracil ring, ribose moiety, and the phosphate chain. For instance, C5-phenyl- or 3-NMe-uridine-5'-α,β-methylene-diphosphonate, 16 and 23, or lack of 2'-OH, in 12-15, resulted in loss of both agonist and antagonist activity toward hP2Y6-R. However, uridylyl phosphosulfate, 19, selectively inhibited hP2Y6-R (IC50 112 μM) versus P2Y2/4-Rs. In summary, we have established a comprehensive SAR for hP2Y6-R ligands towards the development of hP2Y6-R antagonists." @default.
- W808198246 created "2016-06-24" @default.
- W808198246 creator A5000152563 @default.
- W808198246 creator A5012615383 @default.
- W808198246 creator A5018378104 @default.
- W808198246 creator A5043796884 @default.
- W808198246 creator A5045476194 @default.
- W808198246 creator A5046148841 @default.
- W808198246 creator A5053007068 @default.
- W808198246 creator A5058936265 @default.
- W808198246 creator A5079440580 @default.
- W808198246 date "2015-09-01" @default.
- W808198246 modified "2023-09-27" @default.
- W808198246 title "Synthesis and structure–activity relationship of uracil nucleotide derivatives towards the identification of human P2Y 6 receptor antagonists" @default.
- W808198246 cites W1530845853 @default.
- W808198246 cites W1896319706 @default.
- W808198246 cites W1963758499 @default.
- W808198246 cites W1968962803 @default.
- W808198246 cites W1973602718 @default.
- W808198246 cites W1975948912 @default.
- W808198246 cites W1979393217 @default.
- W808198246 cites W1985107522 @default.
- W808198246 cites W1993208660 @default.
- W808198246 cites W1995810932 @default.
- W808198246 cites W1996725520 @default.
- W808198246 cites W1997884817 @default.
- W808198246 cites W2003342088 @default.
- W808198246 cites W2005665778 @default.
- W808198246 cites W2010428132 @default.
- W808198246 cites W2011221727 @default.
- W808198246 cites W2012894470 @default.
- W808198246 cites W2013345697 @default.
- W808198246 cites W2014755783 @default.
- W808198246 cites W2016501431 @default.
- W808198246 cites W2016635800 @default.
- W808198246 cites W2019735814 @default.
- W808198246 cites W2026271678 @default.
- W808198246 cites W2029239108 @default.
- W808198246 cites W2037178734 @default.
- W808198246 cites W2037259253 @default.
- W808198246 cites W2047261592 @default.
- W808198246 cites W2051106220 @default.
- W808198246 cites W2056564141 @default.
- W808198246 cites W2059196610 @default.
- W808198246 cites W2068613384 @default.
- W808198246 cites W2071531212 @default.
- W808198246 cites W2078204905 @default.
- W808198246 cites W2083793459 @default.
- W808198246 cites W2096405956 @default.
- W808198246 cites W2100452437 @default.
- W808198246 cites W2104485689 @default.
- W808198246 cites W2113679306 @default.
- W808198246 cites W2119767998 @default.
- W808198246 cites W2121134314 @default.
- W808198246 cites W2126261604 @default.
- W808198246 cites W2131450595 @default.
- W808198246 cites W2139190743 @default.
- W808198246 cites W2141260882 @default.
- W808198246 cites W2165764474 @default.
- W808198246 cites W2315355035 @default.
- W808198246 cites W2399800726 @default.
- W808198246 cites W2952152653 @default.
- W808198246 doi "https://doi.org/10.1016/j.bmc.2015.07.004" @default.
- W808198246 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26233801" @default.
- W808198246 hasPublicationYear "2015" @default.
- W808198246 type Work @default.
- W808198246 sameAs 808198246 @default.
- W808198246 citedByCount "18" @default.
- W808198246 countsByYear W8081982462016 @default.
- W808198246 countsByYear W8081982462017 @default.
- W808198246 countsByYear W8081982462018 @default.
- W808198246 countsByYear W8081982462019 @default.
- W808198246 countsByYear W8081982462020 @default.
- W808198246 countsByYear W8081982462021 @default.
- W808198246 countsByYear W8081982462022 @default.
- W808198246 countsByYear W8081982462023 @default.
- W808198246 crossrefType "journal-article" @default.
- W808198246 hasAuthorship W808198246A5000152563 @default.
- W808198246 hasAuthorship W808198246A5012615383 @default.
- W808198246 hasAuthorship W808198246A5018378104 @default.
- W808198246 hasAuthorship W808198246A5043796884 @default.
- W808198246 hasAuthorship W808198246A5045476194 @default.
- W808198246 hasAuthorship W808198246A5046148841 @default.
- W808198246 hasAuthorship W808198246A5053007068 @default.
- W808198246 hasAuthorship W808198246A5058936265 @default.
- W808198246 hasAuthorship W808198246A5079440580 @default.
- W808198246 hasConcept C104317684 @default.
- W808198246 hasConcept C114373084 @default.
- W808198246 hasConcept C170493617 @default.
- W808198246 hasConcept C178790620 @default.
- W808198246 hasConcept C181199279 @default.
- W808198246 hasConcept C185592680 @default.
- W808198246 hasConcept C193042331 @default.
- W808198246 hasConcept C202751555 @default.
- W808198246 hasConcept C2776568683 @default.
- W808198246 hasConcept C2776885963 @default.
- W808198246 hasConcept C2777752497 @default.
- W808198246 hasConcept C2778938600 @default.