FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W808219799> ?p ?o ?g. }

• W808219799 endingPage "e0125017" @default.
• W808219799 startingPage "e0125017" @default.
• W808219799 abstract "We recently found that the tetraspanin family member, CD82, which is aberrantly expressed in chemotherapy-resistant CD34(+)/CD38- acute myelogenous leukemia (AML) cells, negatively regulates matrix metalloproteinase 9, and plays an important role in enabling CD34(+)/CD38(-) AML cells to adhere to the bone marrow microenvironment. This study explored novel functions of CD82 that contribute to AML progression.We employed microarray analysis comparing the gene expression profiles between CD34(+)/CD38(-) AML cells transduced with CD82 shRNA and CD34(+)/CD38(-) AML cells transduced with control shRNA. Real-time RT-PCR and western blot analysis were performed to examine the effect of CD82 knockdown on the expression of the polycomb group member, enhancer of zeste homolog 2 (EZH2), in leukemia cells. A chromatin immunoprecipitation assay was performed to examine the effect of CD82 expression on the amount of EZH2 bound to the promoter regions of tumor suppressor genes in leukemia cells. We also utilized methylation-specific PCR to examine whether CD82 expression influences the methylation status of the tumor suppressor gene promoter regions in leukemia cells.Microarray analysis revealed that levels of EZH2 decreased after shRNA-mediated depletion of CD82 in CD34(+)/CD38(-) AML cells. Moreover, the antibody-mediated blockade of CD82 in leukemia cells lowered EZH2 expression via activation of p38 MAPK signaling, decreased the amount of EZH2 bound to the promoter regions of the tumor suppressor genes, and inhibited histone H3 lysine 27 trimethylation in these promoter regions, resulting in upregulation of the tumor suppressors at both the mRNA and protein levels." @default.
• W808219799 created "2016-06-24" @default.
• W808219799 creator A5011318878 @default.
• W808219799 creator A5014347899 @default.
• W808219799 creator A5051889915 @default.
• W808219799 creator A5058133640 @default.
• W808219799 date "2015-05-08" @default.
• W808219799 modified "2023-10-18" @default.
• W808219799 title "Tetraspanin Family Member, CD82, Regulates Expression of EZH2 via Inactivation of p38 MAPK Signaling in Leukemia Cells" @default.
• W808219799 cites W1548072196 @default.
• W808219799 cites W1569638219 @default.
• W808219799 cites W1658127082 @default.
• W808219799 cites W1882777418 @default.
• W808219799 cites W1971107350 @default.
• W808219799 cites W1971313898 @default.
• W808219799 cites W1973577899 @default.
• W808219799 cites W1973723674 @default.
• W808219799 cites W1975994524 @default.
• W808219799 cites W1977261138 @default.
• W808219799 cites W1983641075 @default.
• W808219799 cites W1983979356 @default.
• W808219799 cites W1984731449 @default.
• W808219799 cites W1985243924 @default.
• W808219799 cites W1985347144 @default.
• W808219799 cites W1986764006 @default.
• W808219799 cites W1987742709 @default.
• W808219799 cites W1991962444 @default.
• W808219799 cites W1992361007 @default.
• W808219799 cites W1992514491 @default.
• W808219799 cites W1992887610 @default.
• W808219799 cites W1993362540 @default.
• W808219799 cites W2004842295 @default.
• W808219799 cites W2005986051 @default.
• W808219799 cites W2006945705 @default.
• W808219799 cites W2008376266 @default.
• W808219799 cites W2009886857 @default.
• W808219799 cites W2012192404 @default.
• W808219799 cites W2015132841 @default.
• W808219799 cites W2024373518 @default.
• W808219799 cites W2034203447 @default.
• W808219799 cites W2041897873 @default.
• W808219799 cites W2042561593 @default.
• W808219799 cites W2046291524 @default.
• W808219799 cites W2048386264 @default.
• W808219799 cites W2053737668 @default.
• W808219799 cites W2057769740 @default.
• W808219799 cites W2061846271 @default.
• W808219799 cites W2080699730 @default.
• W808219799 cites W2087249042 @default.
• W808219799 cites W2089122153 @default.
• W808219799 cites W2090642317 @default.
• W808219799 cites W2100438302 @default.
• W808219799 cites W2103062633 @default.
• W808219799 cites W2111342463 @default.
• W808219799 cites W2111737333 @default.
• W808219799 cites W2116507825 @default.
• W808219799 cites W2134983613 @default.
• W808219799 cites W2140254135 @default.
• W808219799 cites W2146038516 @default.
• W808219799 cites W2147370638 @default.
• W808219799 cites W2154476655 @default.
• W808219799 cites W2155819554 @default.
• W808219799 cites W2165894156 @default.
• W808219799 cites W2227640943 @default.
• W808219799 cites W2262513754 @default.
• W808219799 doi "https://doi.org/10.1371/journal.pone.0125017" @default.
• W808219799 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4425466" @default.
• W808219799 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25955299" @default.
• W808219799 hasPublicationYear "2015" @default.
• W808219799 type Work @default.
• W808219799 sameAs 808219799 @default.
• W808219799 citedByCount "16" @default.
• W808219799 countsByYear W8082197992015 @default.
• W808219799 countsByYear W8082197992016 @default.
• W808219799 countsByYear W8082197992017 @default.
• W808219799 countsByYear W8082197992019 @default.
• W808219799 countsByYear W8082197992020 @default.
• W808219799 countsByYear W8082197992021 @default.
• W808219799 countsByYear W8082197992023 @default.
• W808219799 crossrefType "journal-article" @default.
• W808219799 hasAuthorship W808219799A5011318878 @default.
• W808219799 hasAuthorship W808219799A5014347899 @default.
• W808219799 hasAuthorship W808219799A5051889915 @default.
• W808219799 hasAuthorship W808219799A5058133640 @default.
• W808219799 hasBestOaLocation W8082197991 @default.
• W808219799 hasConcept C101762097 @default.
• W808219799 hasConcept C104317684 @default.
• W808219799 hasConcept C119056186 @default.
• W808219799 hasConcept C134320426 @default.
• W808219799 hasConcept C1491633281 @default.
• W808219799 hasConcept C150194340 @default.
• W808219799 hasConcept C153911025 @default.
• W808219799 hasConcept C173396325 @default.
• W808219799 hasConcept C190232843 @default.
• W808219799 hasConcept C203014093 @default.
• W808219799 hasConcept C2777208748 @default.
• W808219799 hasConcept C2778461978 @default.
• W808219799 hasConcept C33288867 @default.

• next