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- W808375794 abstract "Objective To observe the focal cerebral ischemia/reperfusion-induced phosphorylation of c-Jun in rats and investigate the effect of isoflurane. Methods Animal model of global cerebral ischemia was established by ligation of bilateral common carotid and vertebral arteries (four vessels). Healthy male Sprague-Dawley rats were randomly divided into four groups: sham operation group (S), ischemia/reperfusion group (I/R), 2 h 1.5 MAC isoflurane preconditioning+ischemia/reperfusion group (I/R+Iso) and 2 h pure O2 inhalation+ischemia/reperfusion group (I/R+O2). 15 min after global cerebral ischemia, the rats were allowed 6 hours of reperfusion. Determination of phosphorylation of c-Jun was performed by Western blotting and immunohistochemistry. Results The phosphorylation levels of c-Jun in I/R+Iso group was markedly lower than that in I/R and I/R+O2 groups (P＜0.05). Conclusion Isoflurane is able to inhibit the phosphorylation of c-Jun, which might be one of its protective mechanisms in the ischemia/reperfusion-induced brain injuries in rats." @default.
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- W808375794 date "2009-02-25" @default.
- W808375794 modified "2023-09-24" @default.
- W808375794 title "异氟醚对大鼠脑缺血／再灌注诱导c-Jun磷酸化的影响" @default.
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